Myasthenia gravis in pregnancy: Systematic review and case series

BACKGROUND: Myasthenia gravis is an autoimmune disease which can impact pregnancy. METHODS: Six databases were systematically searched for studies with at least five subjects reporting pregnancy outcomes for women with myasthenia gravis in pregnancy. Assessment of bias was performed for all included...

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Detalles Bibliográficos
Autores principales: Banner, Harrison, Niles, Kirsten M, Ryu, Michelle, Sermer, Mathew, Bril, Vera, Murphy, Kellie E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277733/
https://www.ncbi.nlm.nih.gov/pubmed/35845224
http://dx.doi.org/10.1177/1753495X211041899
Descripción
Sumario:BACKGROUND: Myasthenia gravis is an autoimmune disease which can impact pregnancy. METHODS: Six databases were systematically searched for studies with at least five subjects reporting pregnancy outcomes for women with myasthenia gravis in pregnancy. Assessment of bias was performed for all included studies. Forty-eight cases from our own centre were also included in the analysis. RESULTS: In total, 32 publications met inclusion criteria for systematic review, for a total of 33 unique data sets including 48 cases from our institution. Outcome data was available for 824 pregnancies. Spontaneous vaginal delivery occurred in 56.3% of pregnancies. Overall risk of myasthenia gravis exacerbation was 33.8% with a 6.4% risk of myasthenic crisis in pregnancy and 8.2% postpartum. The incidence risk of transient neonatal myasthenia gravis was 13.0%. CONCLUSIONS: The current systematic review provides the best estimates of risk currently available to aid in counselling women with myasthenia gravis in pregnancy.

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