Cargando…

Improvement in insulin sensitivity and prevention of high fat diet-induced liver pathology using a CXCR2 antagonist

BACKGROUND: Liver pathology (LP) characteristic of non-alcoholic fatty acid disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is a prevalent co-morbidity of type 2 diabetes (T2D). Accumulating evidence indicates that neutrophils driving insulin resistance (IR), including hepatic IR, precipitate T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Phillips, Brett E., Lantier, Louise, Engman, Carl, Garciafigueroa, Yesica, Singhi, Aatur, Trucco, Massimo, Mantzoros, Christos, Wasserman, David, Giannoukakis, Nick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277870/ https://www.ncbi.nlm.nih.gov/pubmed/35831885 http://dx.doi.org/10.1186/s12933-022-01564-y

Ejemplares similares

Co-Stimulation-Impaired Bone Marrow-Derived Dendritic Cells Prevent Dextran Sodium Sulfate-Induced Colitis in Mice
por: Engman, Carl, et al.
Publicado: (2018)

Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy
por: Phillips, Brett Eugene, et al.
Publicado: (2019)

Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice
por: Garciafigueroa, Yesica, et al.
Publicado: (2021)

Clinical Tolerogenic Dendritic Cells: Exploring Therapeutic Impact on Human Autoimmune Disease
por: Phillips, Brett Eugene, et al.
Publicado: (2017)

Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation
por: Phillips, Brett E., et al.
Publicado: (2021)

Involvement of Suppressive B-Lymphocytes in the Mechanism of Tolerogenic Dendritic Cell Reversal of Type 1 Diabetes in NOD Mice
por: Di Caro, Valentina, et al.
Publicado: (2014)

Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same?
por: Phillips, Brett, et al.
Publicado: (2011)

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients
por: Giannoukakis, Nick, et al.
Publicado: (2011)

Human Hemangioblast-Derived Mesenchymal Stem Cells Promote Islet Engraftment in a Minimal Islet Mass Transplantation Model in Mice
por: Bertera, Suzanne, et al.
Publicado: (2021)

Uncoupling hepatic insulin resistance – hepatic inflammation to improve insulin sensitivity and to prevent impaired metabolism-associated fatty liver disease in type 2 diabetes
por: Niranjan, Sitara, et al.
Publicado: (2023)

Autoimmune Inflammation and Insulin Resistance: Hallmarks So Far and Yet So Close to Explain Diabetes Endotypes
por: Petrelli, Alessandra, et al.
Publicado: (2021)

SIRT2 knockout exacerbates insulin resistance in high fat-fed mice
por: Lantier, Louise, et al.
Publicado: (2018)

Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance
por: Kang, Li, et al.
Publicado: (2013)

Relaxin Treatment Reverses Insulin Resistance in Mice Fed a High-Fat Diet
por: Bonner, Jeffrey S., et al.
Publicado: (2013)

SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice
por: Lantier, Louise, et al.
Publicado: (2015)

Incidence of an Insulin-Requiring Hyperglycemic Syndrome in SARS-CoV-2–Infected Young Individuals: Is It Type 1 Diabetes?
por: Pietropaolo, Massimo, et al.
Publicado: (2022)

It’s Time to Bring Dendritic Cell Therapy to Type 1 Diabetes
por: Creusot, Rémi J., et al.
Publicado: (2014)

Response to Comment on Pietropaolo et al. Incidence of an Insulin-Requiring Hyperglycemic Syndrome in SARS-CoV-2– Infected Young Individuals: Is It Type 1 Diabetes? Diabetes 2022;71:2656–2663
por: Pietropaolo, Massimo, et al.
Publicado: (2022)

Muscle-Specific Vascular Endothelial Growth Factor Deletion Induces Muscle Capillary Rarefaction Creating Muscle Insulin Resistance
por: Bonner, Jeffrey S., et al.
Publicado: (2013)

CXCR4 antagonists for treatment of breast cancer
por: Cortés, Javier, et al.
Publicado: (2018)

FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver
por: Kim, Dae Hyun, et al.
Publicado: (2011)

β-Catenin Activation in Hepatocellular Cancer: Implications in Biology and Therapy
por: Krutsenko, Yekaterina, et al.
Publicado: (2021)

The Development of INT131 as a Selective PPARγ Modulator: Approach to a Safer Insulin Sensitizer
por: Higgins, Linda S., et al.
Publicado: (2008)

CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking
por: Pluchino, Nicola, et al.
Publicado: (2020)

Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance
por: Williams, Ashley S., et al.
Publicado: (2017)

CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet
por: Kurita, Kenichi, et al.
Publicado: (2019)

Targeting of CXCR4 by the Naturally Occurring CXCR4 Antagonist EPI-X4 in Waldenström’s Macroglobulinemia
por: Kaiser, Lisa Marie, et al.
Publicado: (2021)

PCSK9 inhibition and cholesterol homeostasis in insulin producing β-cells
por: Päth, Günter, et al.
Publicado: (2022)

Tolerogenic dendritic cells in type 1 diabetes: no longer a concept
por: Giannoukakis, Nick
Publicado: (2023)

CCR5 and CXCR4 antagonist and agonist binding sites
por: Teintze, Martin, et al.
Publicado: (2006)

Molecular basis for the antagonistic activity of an anti-CXCR4 antibody
por: Peng, Li, et al.
Publicado: (2015)

Cross-talk between SARS-CoV-2 infection and the insulin/IGF signaling pathway: Implications for metabolic diseases in COVID-19 and for post-acute sequelae of SARS-CoV-2 infection
por: Kelesidis, Theodoros, et al.
Publicado: (2022)

Identification of a Cardiac Specific Protein Transduction Domain by In Vivo Biopanning Using a M13 Phage Peptide Display Library in Mice
por: Zahid, Maliha, et al.
Publicado: (2010)

Novel ALK Fusion, PPFIBP1-ALK, in Pancreatic Ductal Adenocarcinoma Responsive to Alectinib and Lorlatinib
por: Gower, Arjan, et al.
Publicado: (2020)

Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding
por: Khan, Abid, et al.
Publicado: (2007)

CXCR4 antagonists in hematologic malignancies: more than just mobilizers?
por: Jo, Deog-Yeon
Publicado: (2011)

EPI-X4, a novel endogenous antagonist of CXCR4
por: Buske, Christian, et al.
Publicado: (2015)

CXCR4 antagonists suppress small cell lung cancer progression
por: Taromi, Sanaz, et al.
Publicado: (2016)

Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes
por: Petrelli, Alessandra, et al.
Publicado: (2021)

Rosai–Dorfman Disease (Sinus Histiocytosis with Massive Lymphadenopathy) of the Pancreas: Third Reported Occurrence
por: Romero Arenas, Minerva A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_2h44tqttc1hdsdfh0rbfurhrsj