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Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study

The aim of this single-center retrospective study was to investigate the association between the time in range (TIR) of relative normoglycemia (RN) and in-hospital mortality. We defined RN as measured blood glucose in the range of 70–140% of A1C-derived average glucose and absolute normoglycemia (AN...

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Autores principales: Okazaki, Tomoya, Inoue, Akihiko, Taira, Takuya, Nakagawa, Shun, Kawakita, Kenya, Kuroda, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277973/
https://www.ncbi.nlm.nih.gov/pubmed/35831389
http://dx.doi.org/10.1038/s41598-022-15795-2
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author Okazaki, Tomoya
Inoue, Akihiko
Taira, Takuya
Nakagawa, Shun
Kawakita, Kenya
Kuroda, Yasuhiro
author_facet Okazaki, Tomoya
Inoue, Akihiko
Taira, Takuya
Nakagawa, Shun
Kawakita, Kenya
Kuroda, Yasuhiro
author_sort Okazaki, Tomoya
collection PubMed
description The aim of this single-center retrospective study was to investigate the association between the time in range (TIR) of relative normoglycemia (RN) and in-hospital mortality. We defined RN as measured blood glucose in the range of 70–140% of A1C-derived average glucose and absolute normoglycemia (AN) as 70–140 mg/dL. We conducted multivariate logistic regression analyses to examine the association between TIR of RN > 80% or TIR of AN > 80% up to 72 h after ICU admission and in-hospital mortality (Model 1 and Model 2, respectively). The discrimination of the models was assessed using the area under the receiver operating characteristic curve (AUROC). Among 328 patients, 35 died in hospital (11%). Model 1 showed that TIR of RN > 80% was associated with reduced in-hospital mortality (adjusted OR 0.16; 95% CI 0.06–0.43; P < 0. 001); however, Model 2 showed that the TIR of AN > 80% was not. The AUROC of Model 1 was significantly higher than that of Model 2 (0.84 [95% CI 0.77–0.90] vs. 0.79 [0.70–0.87], P = 0.008).Our findings provide a foundation for further studies exploring individualized glycemic management in ICUs.
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spelling pubmed-92779732022-07-14 Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study Okazaki, Tomoya Inoue, Akihiko Taira, Takuya Nakagawa, Shun Kawakita, Kenya Kuroda, Yasuhiro Sci Rep Article The aim of this single-center retrospective study was to investigate the association between the time in range (TIR) of relative normoglycemia (RN) and in-hospital mortality. We defined RN as measured blood glucose in the range of 70–140% of A1C-derived average glucose and absolute normoglycemia (AN) as 70–140 mg/dL. We conducted multivariate logistic regression analyses to examine the association between TIR of RN > 80% or TIR of AN > 80% up to 72 h after ICU admission and in-hospital mortality (Model 1 and Model 2, respectively). The discrimination of the models was assessed using the area under the receiver operating characteristic curve (AUROC). Among 328 patients, 35 died in hospital (11%). Model 1 showed that TIR of RN > 80% was associated with reduced in-hospital mortality (adjusted OR 0.16; 95% CI 0.06–0.43; P < 0. 001); however, Model 2 showed that the TIR of AN > 80% was not. The AUROC of Model 1 was significantly higher than that of Model 2 (0.84 [95% CI 0.77–0.90] vs. 0.79 [0.70–0.87], P = 0.008).Our findings provide a foundation for further studies exploring individualized glycemic management in ICUs. Nature Publishing Group UK 2022-07-13 /pmc/articles/PMC9277973/ /pubmed/35831389 http://dx.doi.org/10.1038/s41598-022-15795-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Okazaki, Tomoya
Inoue, Akihiko
Taira, Takuya
Nakagawa, Shun
Kawakita, Kenya
Kuroda, Yasuhiro
Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study
title Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study
title_full Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study
title_fullStr Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study
title_full_unstemmed Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study
title_short Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study
title_sort association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277973/
https://www.ncbi.nlm.nih.gov/pubmed/35831389
http://dx.doi.org/10.1038/s41598-022-15795-2
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