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Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study
The aim of this single-center retrospective study was to investigate the association between the time in range (TIR) of relative normoglycemia (RN) and in-hospital mortality. We defined RN as measured blood glucose in the range of 70–140% of A1C-derived average glucose and absolute normoglycemia (AN...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277973/ https://www.ncbi.nlm.nih.gov/pubmed/35831389 http://dx.doi.org/10.1038/s41598-022-15795-2 |
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author | Okazaki, Tomoya Inoue, Akihiko Taira, Takuya Nakagawa, Shun Kawakita, Kenya Kuroda, Yasuhiro |
author_facet | Okazaki, Tomoya Inoue, Akihiko Taira, Takuya Nakagawa, Shun Kawakita, Kenya Kuroda, Yasuhiro |
author_sort | Okazaki, Tomoya |
collection | PubMed |
description | The aim of this single-center retrospective study was to investigate the association between the time in range (TIR) of relative normoglycemia (RN) and in-hospital mortality. We defined RN as measured blood glucose in the range of 70–140% of A1C-derived average glucose and absolute normoglycemia (AN) as 70–140 mg/dL. We conducted multivariate logistic regression analyses to examine the association between TIR of RN > 80% or TIR of AN > 80% up to 72 h after ICU admission and in-hospital mortality (Model 1 and Model 2, respectively). The discrimination of the models was assessed using the area under the receiver operating characteristic curve (AUROC). Among 328 patients, 35 died in hospital (11%). Model 1 showed that TIR of RN > 80% was associated with reduced in-hospital mortality (adjusted OR 0.16; 95% CI 0.06–0.43; P < 0. 001); however, Model 2 showed that the TIR of AN > 80% was not. The AUROC of Model 1 was significantly higher than that of Model 2 (0.84 [95% CI 0.77–0.90] vs. 0.79 [0.70–0.87], P = 0.008).Our findings provide a foundation for further studies exploring individualized glycemic management in ICUs. |
format | Online Article Text |
id | pubmed-9277973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-92779732022-07-14 Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study Okazaki, Tomoya Inoue, Akihiko Taira, Takuya Nakagawa, Shun Kawakita, Kenya Kuroda, Yasuhiro Sci Rep Article The aim of this single-center retrospective study was to investigate the association between the time in range (TIR) of relative normoglycemia (RN) and in-hospital mortality. We defined RN as measured blood glucose in the range of 70–140% of A1C-derived average glucose and absolute normoglycemia (AN) as 70–140 mg/dL. We conducted multivariate logistic regression analyses to examine the association between TIR of RN > 80% or TIR of AN > 80% up to 72 h after ICU admission and in-hospital mortality (Model 1 and Model 2, respectively). The discrimination of the models was assessed using the area under the receiver operating characteristic curve (AUROC). Among 328 patients, 35 died in hospital (11%). Model 1 showed that TIR of RN > 80% was associated with reduced in-hospital mortality (adjusted OR 0.16; 95% CI 0.06–0.43; P < 0. 001); however, Model 2 showed that the TIR of AN > 80% was not. The AUROC of Model 1 was significantly higher than that of Model 2 (0.84 [95% CI 0.77–0.90] vs. 0.79 [0.70–0.87], P = 0.008).Our findings provide a foundation for further studies exploring individualized glycemic management in ICUs. Nature Publishing Group UK 2022-07-13 /pmc/articles/PMC9277973/ /pubmed/35831389 http://dx.doi.org/10.1038/s41598-022-15795-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Okazaki, Tomoya Inoue, Akihiko Taira, Takuya Nakagawa, Shun Kawakita, Kenya Kuroda, Yasuhiro Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study |
title | Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study |
title_full | Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study |
title_fullStr | Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study |
title_full_unstemmed | Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study |
title_short | Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study |
title_sort | association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277973/ https://www.ncbi.nlm.nih.gov/pubmed/35831389 http://dx.doi.org/10.1038/s41598-022-15795-2 |
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