A computational algorithm to assess the physiochemical determinants of T cell receptor dissociation kinetics

The rational design of T Cell Receptors (TCRs) for immunotherapy has stagnated due to a limited understanding of the dynamic physiochemical features of the TCR that elicit an immunogenic response. The physiochemical features of the TCR-peptide major histocompatibility complex (pMHC) bond dictate bon...

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Detalles Bibliográficos
Autores principales: Rollins, Zachary A., Huang, Jun, Tagkopoulos, Ilias, Faller, Roland, George, Steven C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278023/
https://www.ncbi.nlm.nih.gov/pubmed/35860406
http://dx.doi.org/10.1016/j.csbj.2022.06.048

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