The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells

Neurosteroids, modulators of neuronal and glial cell functions, are synthesized in the nervous system from cholesterol. In peripheral steroidogenic tissues, cholesterol is converted to the major steroid precursor pregnenolone by the CYP11A1 enzyme. Although pregnenolone is one of the most abundant n...

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Detalles Bibliográficos
Autores principales: Lin, Yiqi Christina, Cheung, Garett, Porter, Edith, Papadopoulos, Vassilios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278081/
https://www.ncbi.nlm.nih.gov/pubmed/35688208
http://dx.doi.org/10.1016/j.jbc.2022.102110

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