Cargando…

Systematic Study on the Cytotoxic Potency of Commonly Used Dimeric Metal Precursors in Human Cancer Cell Lines

The cytotoxicities of seven dimeric metal species of the general formula [M(arene)Cl(2)](2), commonly used as precursors for complex synthesis and deemed biologically inactive, are investigated in seven commonly employed human cancer cell lines. Four of these complexes featured a ruthenium(II) core,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geisler, Heiko, Harringer, Sophia, Wenisch, Dominik, Urban, Richard, Jakupec, Michael A., Kandioller, Wolfgang, Keppler, Bernhard K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278098/ https://www.ncbi.nlm.nih.gov/pubmed/35212190 http://dx.doi.org/10.1002/open.202200019

Ejemplares similares

Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies
por: Geisler, Heiko, et al.
Publicado: (2021)

Arene Variation of Highly Cytotoxic Tridentate Naphthoquinone-Based Ruthenium(II) Complexes and In-Depth In Vitro Studies
por: Cseh, Klaudia, et al.
Publicado: (2022)

Physicochemical Studies and Anticancer Potency of Ruthenium η(6)-p-Cymene Complexes Containing Antibacterial Quinolones
por: Kljun, Jakob, et al.
Publicado: (2011)

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water‐Soluble Thiopyridone‐Based Organometallic Complexes and Their Unexpected (Biological) Behavior
por: Harringer, Sophia, et al.
Publicado: (2020)

Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors
por: Legina, Maria S., et al.
Publicado: (2020)

Investigations on the Anticancer Potential of Benzothiazole-Based Metallacycles
por: Mokesch, Stephan, et al.
Publicado: (2020)

Synthesis and in vitro Antitumor Potency of (Cyclohexane-1,2-Diamine)Platinum(II) Complexes with Aminotris(Methylenephosphonic Acid) as Bone-Seeking Ligand
por: Galanski, Markus, et al.
Publicado: (2005)

Fine-Tuning the Activation Mode of an 1,3-Indandione-Based Ruthenium(II)-Cymene Half-Sandwich Complex by Variation of Its Leaving Group
por: Mokesch, Stephan, et al.
Publicado: (2019)

The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo—A Comparison of O,O‐, S,O‐, and N,N‐Chelate Effects
por: Berasaluce, Iker, et al.
Publicado: (2019)

Novel 3-Hydroxy-2-Naphthoate-Based Task-Specific Ionic Liquids for an Efficient Extraction of Heavy Metals
por: Pirkwieser, Philip, et al.
Publicado: (2018)

Solvent Bar Micro-Extraction of Heavy Metals from Natural Water Samples Using 3-Hydroxy-2-Naphthoate-Based Ionic Liquids
por: Pirkwieser, Philip, et al.
Publicado: (2018)

Diamminetetrakis(carboxylato)platinum(IV) Complexes – Synthesis, Characterization, and Cytotoxicity
por: Hoffmeister, Björn R, et al.
Publicado: (2012)

Theoretical Investigations and Density Functional Theory Based Quantitative Structure–Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes
por: Varbanov, Hristo P., et al.
Publicado: (2012)

Extraction of rare earth elements from aqueous solutions using the ionic liquid trihexyltetradecylphosphonium 3-hydroxy-2-naphthoate
por: Gradwohl, Andreas, et al.
Publicado: (2023)

Anticancer Tungstenocenes with a Diverse Set of (O,O–), (O,S–) and (O,N–) Chelates—A Detailed Biological Study Using an Improved Evaluation via 3D Spheroid Models
por: Cseh, Klaudia, et al.
Publicado: (2023)

Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes—A More Selective Anticancer Treatment?
por: Lerchbammer-Kreith, Yvonne, et al.
Publicado: (2023)

Molecular mode of action of NKP-1339 – a clinically investigated ruthenium-based drug – involves ER- and ROS-related effects in colon carcinoma cell lines
por: Flocke, Lea S., et al.
Publicado: (2016)

Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin
por: Varbanov, Hristo, et al.
Publicado: (2011)

Half-Sandwich Rhodium Complexes with Releasable N-Donor Monodentate Ligands: Solution Chemical Properties and the Possibility for Acidosis Activation
por: Mészáros, János P., et al.
Publicado: (2023)

Extraction of natural radionuclides from aqueous solutions by novel maltolate-based task-specific ionic liquids
por: Platzer, Sonja, et al.
Publicado: (2014)

Highly Aromatic Flavan-3-ol Derivatives from Palaeotropical Artocarpus lacucha Buch.-Ham Possess Radical Scavenging and Antiproliferative Properties
por: Songoen, Weerasak, et al.
Publicado: (2021)

Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles
por: Novak, Maria S., et al.
Publicado: (2016)

Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
por: Mühlgassner, Gerhard, et al.
Publicado: (2012)

NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer
por: Trondl, Robert, et al.
Publicado: (2012)

Single Spheroid Metabolomics: Optimizing Sample Preparation of Three-Dimensional Multicellular Tumor Spheroids
por: Rusz, Mate, et al.
Publicado: (2019)

KP772 overcomes multiple drug resistance in malignant lymphoma and leukemia cells in vitro by inducing Bcl-2-independent apoptosis and upregulation of Harakiri
por: Kater, Lisa, et al.
Publicado: (2021)

Conjugation of Organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and Indolo[3,2-d]benzazepines to Recombinant Human Serum Albumin: a Strategy To Enhance Cytotoxicity in Cancer Cells
por: Stepanenko, Iryna N., et al.
Publicado: (2011)

Photoreduction of Terrigenous Fe‐Humic Substances Leads to Bioavailable Iron in Oceans
por: Blazevic, Amir, et al.
Publicado: (2016)

Photoreduction of Terrigenous Fe‐Humic Substances Leads to Bioavailable Iron in Oceans
por: Blazevic, Amir, et al.
Publicado: (2016)

α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation
por: Trondl, Robert, et al.
Publicado: (2010)

Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation†
por: Schreiber-Brynzak, Ekaterina, et al.
Publicado: (2016)

Condensed ferric dimers for green photocatalytic synthesis of nylon precursors
por: Ide, Yusuke, et al.
Publicado: (2019)

Metal–Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation
por: Filak, Lukas K., et al.
Publicado: (2013)

Influence of in Vitro Assay Setup on the Apparent Cytotoxic Potency of Benzalkonium Chlorides
por: Groothuis, Floris A., et al.
Publicado: (2019)

Highly Cytotoxic Molybdenocenes with Strong Metabolic Effects Inhibit Tumour Growth in Mice
por: Fuchs, Valentin, et al.
Publicado: (2022)

Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody
por: Ahmed, Mahiuddin, et al.
Publicado: (2015)

En Route to Osmium Analogues of KP1019: Synthesis, Structure, Spectroscopic Properties and Antiproliferative Activity of trans-[Os(IV)Cl(4)(Hazole)(2)]
por: Büchel, Gabriel E., et al.
Publicado: (2011)

NanoSIMS combined with fluorescence microscopy as a tool for subcellular imaging of isotopically labeled platinum-based anticancer drugs
por: Legin, Anton A., et al.
Publicado: (2014)

Antishigellosis and Cytotoxic Potency of Crude Extracts and Isolated Constituents from Duranta repens
por: Nikkon, Farjana, et al.
Publicado: (2008)

Probing the Higgs sector at the FCC-ee
por: Harringer, Nico
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_20mtv80q2o7pusq0cfvleb8c9j