Epitope alteration by small molecules and applications in drug discovery

Small molecules and antibodies are normally considered separately in drug discovery, except in the case of covalent conjugates. We unexpectedly discovered several small molecules that could inhibit or enhance antibody–epitope interactions which opens new possibilities in drug discovery and therapeut...

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Detalles Bibliográficos
Autores principales: Zhu, Biyue, Yang, Jing, Van, Richard, Yang, Fan, Yu, Yue, Yu, Astra, Ran, Kathleen, Yin, Keyi, Liang, Yingxia, Shen, Xunuo, Yin, Wei, Choi, Se Hoon, Lu, Ying, Wang, Changning, Shao, Yihan, Shi, Liang, Tanzi, Rudolph E., Zhang, Can, Cheng, Yan, Zhang, Zhirong, Ran, Chongzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278120/
https://www.ncbi.nlm.nih.gov/pubmed/35919434
http://dx.doi.org/10.1039/d2sc02819k

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