Cargando…

SARS-CoV-2 Spike Furin Cleavage Site and S2′ Basic Residues Modulate the Entry Process in a Host Cell-Dependent Manner

SARS-CoV-2 spike (S) envelope glycoprotein constitutes the main determinant of virus entry and the target of host immune response, thus being of great interest for antiviral research. It is constituted of S1 and S2 subunits, which are involved in ACE2 receptor binding and fusion between the viral en...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lavie, Muriel, Dubuisson, Jean, Belouzard, Sandrine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278140/ https://www.ncbi.nlm.nih.gov/pubmed/35678602 http://dx.doi.org/10.1128/jvi.00474-22

Ejemplares similares

Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling
por: Frolova, Elena I., et al.
Publicado: (2022)

Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry
por: Smith, Timothy J., et al.
Publicado: (2023)

Spike Glycoprotein and Host Cell Determinants of SARS-CoV-2 Entry and Cytopathic Effects
por: Nguyen, Hanh T., et al.
Publicado: (2021)

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity
por: Essalmani, Rachid, et al.
Publicado: (2022)

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants
por: Gellenoncourt, Stacy, et al.
Publicado: (2022)

Characterization of CCoV-HuPn-2018 spike protein-mediated viral entry
por: Liu, Yongmei, et al.
Publicado: (2023)

Characterization of Entry Pathways, Species-Specific Angiotensin-Converting Enzyme 2 Residues Determining Entry, and Antibody Neutralization Evasion of Omicron BA.1, BA.1.1, BA.2, and BA.3 Variants
por: Neerukonda, Sabari Nath, et al.
Publicado: (2022)

Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease
por: Kreutzberger, Alex J. B., et al.
Publicado: (2021)

Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry
por: Choi, Sheyne S. A., et al.
Publicado: (2022)

TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry
por: Haga, Ismar R., et al.
Publicado: (2014)

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase
por: Kettunen, Pinja, et al.
Publicado: (2023)

Variations in Cell Surface ACE2 Levels Alter Direct Binding of SARS-CoV-2 Spike Protein and Viral Infectivity: Implications for Measuring Spike Protein Interactions with Animal ACE2 Orthologs
por: Kazemi, Soheila, et al.
Publicado: (2022)

Sialic Acid Binding Sites in VP2 of Bluetongue Virus and Their Use during Virus Entry
por: Wu, Weining, et al.
Publicado: (2022)

Mapping the pH Sensors Critical for Host Cell Entry by a Complex Nonenveloped Virus
por: Wu, Weining, et al.
Publicado: (2019)

The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry
por: Wang, Guangwen, et al.
Publicado: (2020)

LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2
por: Zhao, Xuesen, et al.
Publicado: (2020)

Single-Virus Fusion Measurements Reveal Multiple Mechanistically Equivalent Pathways for SARS-CoV-2 Entry
por: Sengar, Anjali, et al.
Publicado: (2023)

Herpes Simplex Virus 2 Counteracts Neurite Outgrowth Repulsion during Infection in a Nerve Growth Factor-Dependent Manner
por: Kropp, Kai A., et al.
Publicado: (2020)

The “LLQY” Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus Particles
por: Du, Shouwen, et al.
Publicado: (2022)

Natural and Recombinant SARS-CoV-2 Isolates Rapidly Evolve In Vitro to Higher Infectivity through More Efficient Binding to Heparan Sulfate and Reduced S1/S2 Cleavage
por: Shiliaev, Nikita, et al.
Publicado: (2021)

Single-Particle Detection of Transcription following Rotavirus Entry
por: Salgado, Eric N., et al.
Publicado: (2017)

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry
por: Wan, Yushun, et al.
Publicado: (2020)

Transferrin Receptor Protein 1 Is an Entry Factor for Rabies Virus
por: Wang, Xinxin, et al.
Publicado: (2023)

Visualization of Calcium Ion Loss from Rotavirus during Cell Entry
por: Salgado, Eric N., et al.
Publicado: (2018)

Efficient clathrin-mediated entry of enteric adenoviruses in human duodenal cells
por: Becker, Miriam, et al.
Publicado: (2023)

Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition
por: Navaratnarajah, Chanakha K., et al.
Publicado: (2021)

Porcine Hemagglutinating Encephalomyelitis Virus Enters Neuro-2a Cells via Clathrin-Mediated Endocytosis in a Rab5-, Cholesterol-, and pH-Dependent Manner
por: Li, Zi, et al.
Publicado: (2017)

Bub1 Facilitates Virus Entry through Endocytosis in a Model of Drosophila Pathogenesis
por: Yang, Shuo, et al.
Publicado: (2018)

SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation
por: Hörnich, Bojan F., et al.
Publicado: (2021)

Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling
por: Andrews, Daniel D. T., et al.
Publicado: (2023)

The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies
por: Chan, Conrad En-Zuo, et al.
Publicado: (2022)

V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity
por: Ou, Junxian, et al.
Publicado: (2021)

PJA1 Coordinates with the SMC5/6 Complex To Restrict DNA Viruses and Episomal Genes in an Interferon-Independent Manner
por: Xu, Wei, et al.
Publicado: (2018)

Biochemical Analysis of Coronavirus Spike Glycoprotein Conformational Intermediates during Membrane Fusion
por: Kawase, Miyuki, et al.
Publicado: (2019)

Filoviruses Use the HOPS Complex and UVRAG To Traffic to Niemann-Pick C1 Compartments during Viral Entry
por: Bo, Yuxia, et al.
Publicado: (2020)

GB Virus B and Hepatitis C Virus, Distantly Related Hepaciviruses, Share an Entry Factor, Claudin-1
por: Toon, Kamilla, et al.
Publicado: (2023)

A So-Far Overlooked Secondary Conformation State in the Binding Mode of SARS-CoV-2 Spike Protein to Human ACE2 and Its Conversion Rate Are Crucial for Estimating Infectivity Efficacy of the Underlying Virus Variant
por: Sevenich, Marc, et al.
Publicado: (2022)

CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner
por: Furlong, Kevin, et al.
Publicado: (2020)

Potential Differences in Cleavage of the S Protein and Type 1 Interferon Together Control Human Coronavirus Infection, Propagation, and Neuropathology within the Central Nervous System
por: Le Coupanec, Alain, et al.
Publicado: (2021)

N-(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide Δ4-Desaturase 1-Independent Mechanism
por: Hayashi, Yasuhiro, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_n7uqvf72vkfj6n7nppcqjloc9c