Forkhead O Transcription Factor 4 Restricts HBV Covalently Closed Circular DNA Transcription and HBV Replication through Genetic Downregulation of Hepatocyte Nuclear Factor 4 Alpha and Epigenetic Suppression of Covalently Closed Circular DNA via Interacting with Promyelocytic Leukemia Protein

Nuclear located hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) remains the key obstacle to cure chronic hepatitis B (CHB). In our previous investigation, it was found that FoxO4 could inhibit HBV core promoter activity through downregulating the expression of HNF4α. However, the exa...

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Detalles Bibliográficos
Autores principales: Li, Yuqi, He, Minjing, Gong, Ruijie, Wang, Ziteng, Lu, Lin, Peng, Shu, Duan, Zhiyun, Feng, Ying, Liu, Yi, Gao, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278149/
https://www.ncbi.nlm.nih.gov/pubmed/35695580
http://dx.doi.org/10.1128/jvi.00546-22

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