Cloaking the ACE2 receptor with salivary cationic proteins inhibits SARS-CoV-2 entry

Saliva contributes to the innate immune system, which suggests that it can prevent SARS-CoV-2 entry. We studied the ability of healthy salivary proteins to bind to angiotensin-converting enzyme 2 (ACE2) using biolayer interferometry and pull-down assays. Their effects on binding between the receptor...

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Detalles Bibliográficos
Autores principales: Yoshizato, Katsutoshi, Taira, Toshio, Sato-Matsubara, Misako, Sekiguchi, Shizuko, Yabunaka, Yoriko, Kira, Yukimi, Ohashi, Tetsu, Daikoku, Atsuko, Ofusa, Ken, Kadono, Chiho, Oikawa, Daisuke, Matsubara, Tsutomu, Nakagama, Yu, Kido, Yasutoshi, Tokunaga, Fuminori, Ikeda, Kazuo, Kaneko, Akira, Kawada, Norifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Regular Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278198/
https://www.ncbi.nlm.nih.gov/pubmed/35792074
http://dx.doi.org/10.1093/jb/mvac054

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