Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome 

 : The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks...

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Autores principales: Streng, Bianca M M, Bont, Marin, Delemarre, Eveline M, Binnendijk, Rob S, Smit, Gaby, den Hartog, Gerco, Coppus, Antonia M W, de Vries, Esther, Weijerman, Michel E, Lamberts, Regina, de Graaf, Gert, van der Klis, Fiona R, Vidarsson, Gestur, Rave, Neele, Bont, Louis J, Wildenbeest, Joanne G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278229/
https://www.ncbi.nlm.nih.gov/pubmed/35748853
http://dx.doi.org/10.1093/infdis/jiac235
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author Streng, Bianca M M
Bont, Marin
Delemarre, Eveline M
Binnendijk, Rob S
Smit, Gaby
den Hartog, Gerco
Coppus, Antonia M W
de Vries, Esther
Weijerman, Michel E
Lamberts, Regina
de Graaf, Gert
van der Klis, Fiona R
Vidarsson, Gestur
Rave, Neele
Bont, Louis J
Wildenbeest, Joanne G
author_facet Streng, Bianca M M
Bont, Marin
Delemarre, Eveline M
Binnendijk, Rob S
Smit, Gaby
den Hartog, Gerco
Coppus, Antonia M W
de Vries, Esther
Weijerman, Michel E
Lamberts, Regina
de Graaf, Gert
van der Klis, Fiona R
Vidarsson, Gestur
Rave, Neele
Bont, Louis J
Wildenbeest, Joanne G
author_sort Streng, Bianca M M
collection PubMed
description  : The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1–specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]–1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age. CLINICAL TRIALS REGISTRATION: NCT05145348.
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spelling pubmed-92782292022-07-18 Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome  Streng, Bianca M M Bont, Marin Delemarre, Eveline M Binnendijk, Rob S Smit, Gaby den Hartog, Gerco Coppus, Antonia M W de Vries, Esther Weijerman, Michel E Lamberts, Regina de Graaf, Gert van der Klis, Fiona R Vidarsson, Gestur Rave, Neele Bont, Louis J Wildenbeest, Joanne G J Infect Dis Brief Report  : The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1–specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]–1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age. CLINICAL TRIALS REGISTRATION: NCT05145348. Oxford University Press 2022-06-24 /pmc/articles/PMC9278229/ /pubmed/35748853 http://dx.doi.org/10.1093/infdis/jiac235 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Streng, Bianca M M
Bont, Marin
Delemarre, Eveline M
Binnendijk, Rob S
Smit, Gaby
den Hartog, Gerco
Coppus, Antonia M W
de Vries, Esther
Weijerman, Michel E
Lamberts, Regina
de Graaf, Gert
van der Klis, Fiona R
Vidarsson, Gestur
Rave, Neele
Bont, Louis J
Wildenbeest, Joanne G
Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome 
title Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome 
title_full Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome 
title_fullStr Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome 
title_full_unstemmed Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome 
title_short Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome 
title_sort decreased antibody response after severe acute respiratory syndrome coronavirus 2 vaccination in patients with down syndrome 
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278229/
https://www.ncbi.nlm.nih.gov/pubmed/35748853
http://dx.doi.org/10.1093/infdis/jiac235
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