Structural, functional, and immunogenicity implications of F9 gene recoding

Hemophilia B is a blood clotting disorder caused by deficient activity of coagulation factor IX (FIX). Multiple recombinant FIX proteins are currently approved to treat hemophilia B, and several gene therapy products are currently being developed. Codon optimization is a frequently used technique in...

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Detalles Bibliográficos
Autores principales: Katneni, Upendra K., Alexaki, Aikaterini, Hunt, Ryan C., Hamasaki-Katagiri, Nobuko, Hettiarachchi, Gaya K., Kames, Jacob M., McGill, Joseph R., Holcomb, David D., Athey, John C., Lin, Brian, Parunov, Leonid A., Kafri, Tal, Lu, Qi, Peters, Robert, Ovanesov, Mikhail V., Freedberg, Darón I., Bar, Haim, Komar, Anton A., Sauna, Zuben E., Kimchi-Sarfaty, Chava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278298/
https://www.ncbi.nlm.nih.gov/pubmed/35413099
http://dx.doi.org/10.1182/bloodadvances.2022007094

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