An umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles

We have described the first example of an umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition between two aryl aldehydes and a nitrile under the influence of TMSOTf that proceeds through the formation of N–C, O–C and C–C bonds providing a simple synthetic protocol for obtaining 2,4,5-tris...

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Autores principales: Basavaiah, Deevi, Golime, Gangadhararao, Banoth, Shivalal, Todeti, Saidulu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278343/
https://www.ncbi.nlm.nih.gov/pubmed/35919435
http://dx.doi.org/10.1039/d2sc00046f
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author Basavaiah, Deevi
Golime, Gangadhararao
Banoth, Shivalal
Todeti, Saidulu
author_facet Basavaiah, Deevi
Golime, Gangadhararao
Banoth, Shivalal
Todeti, Saidulu
author_sort Basavaiah, Deevi
collection PubMed
description We have described the first example of an umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition between two aryl aldehydes and a nitrile under the influence of TMSOTf that proceeds through the formation of N–C, O–C and C–C bonds providing a simple synthetic protocol for obtaining 2,4,5-trisubstituted oxazoles.
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spelling pubmed-92783432022-08-01 An umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles Basavaiah, Deevi Golime, Gangadhararao Banoth, Shivalal Todeti, Saidulu Chem Sci Chemistry We have described the first example of an umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition between two aryl aldehydes and a nitrile under the influence of TMSOTf that proceeds through the formation of N–C, O–C and C–C bonds providing a simple synthetic protocol for obtaining 2,4,5-trisubstituted oxazoles. The Royal Society of Chemistry 2022-06-11 /pmc/articles/PMC9278343/ /pubmed/35919435 http://dx.doi.org/10.1039/d2sc00046f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Basavaiah, Deevi
Golime, Gangadhararao
Banoth, Shivalal
Todeti, Saidulu
An umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles
title An umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles
title_full An umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles
title_fullStr An umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles
title_full_unstemmed An umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles
title_short An umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles
title_sort umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278343/
https://www.ncbi.nlm.nih.gov/pubmed/35919435
http://dx.doi.org/10.1039/d2sc00046f
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