Isothiourea-Catalyzed Enantioselective Michael Addition of Malonates to α,β-Unsaturated Aryl Esters

[Image: see text] An enantioselective Michael addition of malonates to α,β-unsaturated para-nitrophenyl esters was achieved using the Lewis basic isothiourea HyperBTM, giving excellent levels of product enantioselectivity (up to >99:1 enantiomeric ratio) in good yields and with complete regiosele...

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Detalles Bibliográficos
Autores principales: Wu, Jiufeng, Young, Claire M., Watts, Amy A., Slawin, Alexandra M. Z., Boyce, Gregory R., Bühl, Michael, Smith, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278409/
https://www.ncbi.nlm.nih.gov/pubmed/35652512
http://dx.doi.org/10.1021/acs.orglett.2c01486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278409/
https://www.ncbi.nlm.nih.gov/pubmed/35652512
http://dx.doi.org/10.1021/acs.orglett.2c01486

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