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Isothiourea-Catalyzed Enantioselective Michael Addition of Malonates to α,β-Unsaturated Aryl Esters
[Image: see text] An enantioselective Michael addition of malonates to α,β-unsaturated para-nitrophenyl esters was achieved using the Lewis basic isothiourea HyperBTM, giving excellent levels of product enantioselectivity (up to >99:1 enantiomeric ratio) in good yields and with complete regiosele...
Autores principales: | Wu, Jiufeng, Young, Claire M., Watts, Amy A., Slawin, Alexandra M. Z., Boyce, Gregory R., Bühl, Michael, Smith, Andrew D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278409/ https://www.ncbi.nlm.nih.gov/pubmed/35652512 http://dx.doi.org/10.1021/acs.orglett.2c01486 |
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