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Cell senescence, rapamycin and hyperfunction theory of aging
A hallmark of cellular senescence is proliferation-like activity of growth-promoting pathways (such as mTOR and MAPK) in non-proliferating cells. When the cell cycle is arrested, these pathways convert arrest to senescence (geroconversion), rendering cells hypertrophic, beta-Gal-positive and hyperfu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278457/ https://www.ncbi.nlm.nih.gov/pubmed/35358003 http://dx.doi.org/10.1080/15384101.2022.2054636 |