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Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study

OBJECTIVES: Adequate maternal thyroid hormone availability is crucial for fetal neurodevelopment, but the role of maternal mild hypothyroidism is not clear. We aim to investigate the association of maternal mild hypothyroidism with neurodevelopment in infants at 1 year of age among TPOAb-negative wo...

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Autores principales: Wang, Qingru, Jiang, Yangqian, Lv, Hong, Lu, Qun, Tao, Shiyao, Qin, Rui, Huang, Lei, Liu, Cong, Xu, Xin, Lv, Siyuan, Li, Mei, Li, Zhi, Du, Jiangbo, Lin, Yuan, Ma, Hongxia, Chi, Xia, Hu, Zhibin, Jiang, Tao, Zhang, Guoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278520/
https://www.ncbi.nlm.nih.gov/pubmed/35846339
http://dx.doi.org/10.3389/fendo.2022.884851
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author Wang, Qingru
Jiang, Yangqian
Lv, Hong
Lu, Qun
Tao, Shiyao
Qin, Rui
Huang, Lei
Liu, Cong
Xu, Xin
Lv, Siyuan
Li, Mei
Li, Zhi
Du, Jiangbo
Lin, Yuan
Ma, Hongxia
Chi, Xia
Hu, Zhibin
Jiang, Tao
Zhang, Guoying
author_facet Wang, Qingru
Jiang, Yangqian
Lv, Hong
Lu, Qun
Tao, Shiyao
Qin, Rui
Huang, Lei
Liu, Cong
Xu, Xin
Lv, Siyuan
Li, Mei
Li, Zhi
Du, Jiangbo
Lin, Yuan
Ma, Hongxia
Chi, Xia
Hu, Zhibin
Jiang, Tao
Zhang, Guoying
author_sort Wang, Qingru
collection PubMed
description OBJECTIVES: Adequate maternal thyroid hormone availability is crucial for fetal neurodevelopment, but the role of maternal mild hypothyroidism is not clear. We aim to investigate the association of maternal mild hypothyroidism with neurodevelopment in infants at 1 year of age among TPOAb-negative women. METHODS: The present study was conducted within the Jiangsu Birth Cohort. A total of 793 mother–infant pairs were eligible for the present study. Maternal thyroid function was assessed by measuring serum thyroid-stimulating hormone, free thyroxine, and thyroid peroxidase antibodies. Neurodevelopment of infants was assessed by using the Bayley Scales of Infant and Toddler Development third edition screening test (Bayley-III screening test). RESULTS: In the multivariate adjusted linear regression analyses, infants of women with subclinical hypothyroidism and isolated hypothyroxinemia were associated with decreased receptive communication scores (β = −0.68, p = 0.034) and decreased gross motor scores (β = −0.83, p = 0.008), respectively. Moreover, infants of women with high-normal TSH concentrations (3.0–4.0 mIU/L) and low FT4 concentrations were significantly associated with lower gross motor scores (β = −1.19, p = 0.032), while no differences were observed in infants when the mothers had a high-normal TSH concentration and normal FT4 levels. CONCLUSIONS: Maternal subclinical hypothyroidism is associated with decreased receptive communication scores in infants at 1 year of age. In addition, maternal TSH concentration greater than 4.0 mIU/L and maternal isolated hypothyroxinemia are associated with impaired gross motor ability of infants, especially in infants of women with high-normal TSH concentrations (3.0–4.0 mIU/L).
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spelling pubmed-92785202022-07-14 Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study Wang, Qingru Jiang, Yangqian Lv, Hong Lu, Qun Tao, Shiyao Qin, Rui Huang, Lei Liu, Cong Xu, Xin Lv, Siyuan Li, Mei Li, Zhi Du, Jiangbo Lin, Yuan Ma, Hongxia Chi, Xia Hu, Zhibin Jiang, Tao Zhang, Guoying Front Endocrinol (Lausanne) Endocrinology OBJECTIVES: Adequate maternal thyroid hormone availability is crucial for fetal neurodevelopment, but the role of maternal mild hypothyroidism is not clear. We aim to investigate the association of maternal mild hypothyroidism with neurodevelopment in infants at 1 year of age among TPOAb-negative women. METHODS: The present study was conducted within the Jiangsu Birth Cohort. A total of 793 mother–infant pairs were eligible for the present study. Maternal thyroid function was assessed by measuring serum thyroid-stimulating hormone, free thyroxine, and thyroid peroxidase antibodies. Neurodevelopment of infants was assessed by using the Bayley Scales of Infant and Toddler Development third edition screening test (Bayley-III screening test). RESULTS: In the multivariate adjusted linear regression analyses, infants of women with subclinical hypothyroidism and isolated hypothyroxinemia were associated with decreased receptive communication scores (β = −0.68, p = 0.034) and decreased gross motor scores (β = −0.83, p = 0.008), respectively. Moreover, infants of women with high-normal TSH concentrations (3.0–4.0 mIU/L) and low FT4 concentrations were significantly associated with lower gross motor scores (β = −1.19, p = 0.032), while no differences were observed in infants when the mothers had a high-normal TSH concentration and normal FT4 levels. CONCLUSIONS: Maternal subclinical hypothyroidism is associated with decreased receptive communication scores in infants at 1 year of age. In addition, maternal TSH concentration greater than 4.0 mIU/L and maternal isolated hypothyroxinemia are associated with impaired gross motor ability of infants, especially in infants of women with high-normal TSH concentrations (3.0–4.0 mIU/L). Frontiers Media S.A. 2022-06-29 /pmc/articles/PMC9278520/ /pubmed/35846339 http://dx.doi.org/10.3389/fendo.2022.884851 Text en Copyright © 2022 Wang, Jiang, Lv, Lu, Tao, Qin, Huang, Liu, Xu, Lv, Li, Li, Du, Lin, Ma, Chi, Hu, Jiang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wang, Qingru
Jiang, Yangqian
Lv, Hong
Lu, Qun
Tao, Shiyao
Qin, Rui
Huang, Lei
Liu, Cong
Xu, Xin
Lv, Siyuan
Li, Mei
Li, Zhi
Du, Jiangbo
Lin, Yuan
Ma, Hongxia
Chi, Xia
Hu, Zhibin
Jiang, Tao
Zhang, Guoying
Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study
title Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study
title_full Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study
title_fullStr Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study
title_full_unstemmed Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study
title_short Association of Maternal Mild Hypothyroidism With Offspring Neurodevelopment in TPOAb-Negative Women: A Prospective Cohort Study
title_sort association of maternal mild hypothyroidism with offspring neurodevelopment in tpoab-negative women: a prospective cohort study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278520/
https://www.ncbi.nlm.nih.gov/pubmed/35846339
http://dx.doi.org/10.3389/fendo.2022.884851
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