Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp(2))–H Functionalization

[Image: see text] The palladium-catalyzed C(sp(2))–H functionalization of bromoaryl aldonitrones leading to benzocyclobutenone-derived ketonitrones is described. This method allows for the preparation of a wide range of strained, four-membered ketonitrones with broad functional group tolerance. Down...

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Autores principales: Brześkiewicz, Jakub, Loska, Rafał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278523/
https://www.ncbi.nlm.nih.gov/pubmed/35613705
http://dx.doi.org/10.1021/acs.orglett.2c01317
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author Brześkiewicz, Jakub
Loska, Rafał
author_facet Brześkiewicz, Jakub
Loska, Rafał
author_sort Brześkiewicz, Jakub
collection PubMed
description [Image: see text] The palladium-catalyzed C(sp(2))–H functionalization of bromoaryl aldonitrones leading to benzocyclobutenone-derived ketonitrones is described. This method allows for the preparation of a wide range of strained, four-membered ketonitrones with broad functional group tolerance. Downstream transformations of the formed products were readily demonstrated, illustrating the synthetic utility of the obtained benzocyclobutenone-derived nitrones for the construction of polycyclic nitrogen-containing scaffolds.
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spelling pubmed-92785232022-07-14 Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp(2))–H Functionalization Brześkiewicz, Jakub Loska, Rafał Org Lett [Image: see text] The palladium-catalyzed C(sp(2))–H functionalization of bromoaryl aldonitrones leading to benzocyclobutenone-derived ketonitrones is described. This method allows for the preparation of a wide range of strained, four-membered ketonitrones with broad functional group tolerance. Downstream transformations of the formed products were readily demonstrated, illustrating the synthetic utility of the obtained benzocyclobutenone-derived nitrones for the construction of polycyclic nitrogen-containing scaffolds. American Chemical Society 2022-05-25 2022-06-10 /pmc/articles/PMC9278523/ /pubmed/35613705 http://dx.doi.org/10.1021/acs.orglett.2c01317 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brześkiewicz, Jakub
Loska, Rafał
Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp(2))–H Functionalization
title Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp(2))–H Functionalization
title_full Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp(2))–H Functionalization
title_fullStr Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp(2))–H Functionalization
title_full_unstemmed Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp(2))–H Functionalization
title_short Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp(2))–H Functionalization
title_sort palladium-catalyzed access to benzocyclobutenone-derived ketonitrones via c(sp(2))–h functionalization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278523/
https://www.ncbi.nlm.nih.gov/pubmed/35613705
http://dx.doi.org/10.1021/acs.orglett.2c01317
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