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Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study

We aimed to evaluate the prospective association of vitamin B5 with all‐cause mortality and explore its potential modifiers in Chinese adults with hypertension. A nested, case‐control study was conducted in the China Stroke Primary Prevention Trial, including 505 deaths of all causes and 505 matched...

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Autores principales: Hong, Yuan, Zhou, Ziyi, Zhang, Nan, He, Qiangqiang, Guo, Zhangyou, Liu, Lishun, Song, Yun, Chen, Ping, Wei, Yaping, Xu, Qiuyue, Li, Ya, Wang, Binyan, Qin, Xianhui, Xu, Xiping, Duan, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278592/
https://www.ncbi.nlm.nih.gov/pubmed/35699663
http://dx.doi.org/10.1111/jch.14516
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author Hong, Yuan
Zhou, Ziyi
Zhang, Nan
He, Qiangqiang
Guo, Zhangyou
Liu, Lishun
Song, Yun
Chen, Ping
Wei, Yaping
Xu, Qiuyue
Li, Ya
Wang, Binyan
Qin, Xianhui
Xu, Xiping
Duan, Yong
author_facet Hong, Yuan
Zhou, Ziyi
Zhang, Nan
He, Qiangqiang
Guo, Zhangyou
Liu, Lishun
Song, Yun
Chen, Ping
Wei, Yaping
Xu, Qiuyue
Li, Ya
Wang, Binyan
Qin, Xianhui
Xu, Xiping
Duan, Yong
author_sort Hong, Yuan
collection PubMed
description We aimed to evaluate the prospective association of vitamin B5 with all‐cause mortality and explore its potential modifiers in Chinese adults with hypertension. A nested, case‐control study was conducted in the China Stroke Primary Prevention Trial, including 505 deaths of all causes and 505 matched controls. The median follow‐up duration was 4.5 years. The primary outcome measure in this investigation was all‐cause mortality, which encompassed deaths for any reason. The mean plasma vitamin B5 concentration for cases (43.7 ng/mL) was higher than that in controls (40.9 ng/mL) (p = .001). When vitamin B5 was further assessed as quintiles, compared with the reference group (Q1: < 33.0 ng/mL), the risk of all‐cause mortality increased by 29% (OR = 1.29, 95% CI: 0.83‐2.01) in Q2, 22% (OR = 1.22, 95% CI: 0.77‐1.94) in Q3, 62% (OR = 1.62, 95% CI: 1.00‐2.62) in Q4, and 77% (OR = 1.77, 95% CI: 1.06‐2.95) in Q5. The trend test was significant (p = .022). When Q4‐Q5 were combined, a significant 41% increment (OR = 1.41, 95% CI: 1.03‐1.95) in all‐cause death risk was found compared with Q1‐Q3. The adverse effects were more pronounced in those with normal folate levels (p‐interaction = .019) and older people (p‐interaction = .037). This study suggests that higher baseline levels of plasma vitamin B5 are a risk factor for all‐cause mortality among Chinese patients with hypertension, especially among older adults and those with adequate folate levels. The findings, if confirmed, may inform novel clinical and nutritional guidelines and interventions to optimize vitamin B5 levels.
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spelling pubmed-92785922022-07-15 Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study Hong, Yuan Zhou, Ziyi Zhang, Nan He, Qiangqiang Guo, Zhangyou Liu, Lishun Song, Yun Chen, Ping Wei, Yaping Xu, Qiuyue Li, Ya Wang, Binyan Qin, Xianhui Xu, Xiping Duan, Yong J Clin Hypertens (Greenwich) Vitamin We aimed to evaluate the prospective association of vitamin B5 with all‐cause mortality and explore its potential modifiers in Chinese adults with hypertension. A nested, case‐control study was conducted in the China Stroke Primary Prevention Trial, including 505 deaths of all causes and 505 matched controls. The median follow‐up duration was 4.5 years. The primary outcome measure in this investigation was all‐cause mortality, which encompassed deaths for any reason. The mean plasma vitamin B5 concentration for cases (43.7 ng/mL) was higher than that in controls (40.9 ng/mL) (p = .001). When vitamin B5 was further assessed as quintiles, compared with the reference group (Q1: < 33.0 ng/mL), the risk of all‐cause mortality increased by 29% (OR = 1.29, 95% CI: 0.83‐2.01) in Q2, 22% (OR = 1.22, 95% CI: 0.77‐1.94) in Q3, 62% (OR = 1.62, 95% CI: 1.00‐2.62) in Q4, and 77% (OR = 1.77, 95% CI: 1.06‐2.95) in Q5. The trend test was significant (p = .022). When Q4‐Q5 were combined, a significant 41% increment (OR = 1.41, 95% CI: 1.03‐1.95) in all‐cause death risk was found compared with Q1‐Q3. The adverse effects were more pronounced in those with normal folate levels (p‐interaction = .019) and older people (p‐interaction = .037). This study suggests that higher baseline levels of plasma vitamin B5 are a risk factor for all‐cause mortality among Chinese patients with hypertension, especially among older adults and those with adequate folate levels. The findings, if confirmed, may inform novel clinical and nutritional guidelines and interventions to optimize vitamin B5 levels. John Wiley and Sons Inc. 2022-06-14 /pmc/articles/PMC9278592/ /pubmed/35699663 http://dx.doi.org/10.1111/jch.14516 Text en © 2022 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Vitamin
Hong, Yuan
Zhou, Ziyi
Zhang, Nan
He, Qiangqiang
Guo, Zhangyou
Liu, Lishun
Song, Yun
Chen, Ping
Wei, Yaping
Xu, Qiuyue
Li, Ya
Wang, Binyan
Qin, Xianhui
Xu, Xiping
Duan, Yong
Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study
title Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study
title_full Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study
title_fullStr Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study
title_full_unstemmed Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study
title_short Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study
title_sort association between plasma vitamin b5 levels and all‐cause mortality: a nested case‐control study
topic Vitamin
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278592/
https://www.ncbi.nlm.nih.gov/pubmed/35699663
http://dx.doi.org/10.1111/jch.14516
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