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Biological Effectiveness of Ion Beam for In Vitro Cell Irradiations

Despite numerous ion beam irradiation of cell experiments performed over the past five decades, the relationship between the biological effectiveness of ion beams and the physical characteristics of the ion beam remains unclear. Using 1,118 sets of in vitro cell survival experiments with ion beam ir...

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Detalles Bibliográficos
Autor principal: Li, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278697/
https://www.ncbi.nlm.nih.gov/pubmed/35847895
http://dx.doi.org/10.3389/fonc.2022.847090
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author Li, Heng
author_facet Li, Heng
author_sort Li, Heng
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description Despite numerous ion beam irradiation of cell experiments performed over the past five decades, the relationship between the biological effectiveness of ion beams and the physical characteristics of the ion beam remains unclear. Using 1,118 sets of in vitro cell survival experiments with ion beam irradiation, compiled by the Particle Irradiation Data Ensemble (PIDE) project, the relationship between cell survival and the fluence and linear energy transfer (LET) of the ion beam was established. Unlike previous studies, the closed-form analytical function is independent of photon irradiation and takes a universal form across all ion and cell species. A new understanding of the biological effectiveness of ion beams is crucial for predicting tumor response and toxicities in ion beam radiation therapy, along with radiation protection for high-LET ion beams with low fluence.
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spelling pubmed-92786972022-07-14 Biological Effectiveness of Ion Beam for In Vitro Cell Irradiations Li, Heng Front Oncol Oncology Despite numerous ion beam irradiation of cell experiments performed over the past five decades, the relationship between the biological effectiveness of ion beams and the physical characteristics of the ion beam remains unclear. Using 1,118 sets of in vitro cell survival experiments with ion beam irradiation, compiled by the Particle Irradiation Data Ensemble (PIDE) project, the relationship between cell survival and the fluence and linear energy transfer (LET) of the ion beam was established. Unlike previous studies, the closed-form analytical function is independent of photon irradiation and takes a universal form across all ion and cell species. A new understanding of the biological effectiveness of ion beams is crucial for predicting tumor response and toxicities in ion beam radiation therapy, along with radiation protection for high-LET ion beams with low fluence. Frontiers Media S.A. 2022-06-29 /pmc/articles/PMC9278697/ /pubmed/35847895 http://dx.doi.org/10.3389/fonc.2022.847090 Text en Copyright © 2022 Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Heng
Biological Effectiveness of Ion Beam for In Vitro Cell Irradiations
title Biological Effectiveness of Ion Beam for In Vitro Cell Irradiations
title_full Biological Effectiveness of Ion Beam for In Vitro Cell Irradiations
title_fullStr Biological Effectiveness of Ion Beam for In Vitro Cell Irradiations
title_full_unstemmed Biological Effectiveness of Ion Beam for In Vitro Cell Irradiations
title_short Biological Effectiveness of Ion Beam for In Vitro Cell Irradiations
title_sort biological effectiveness of ion beam for in vitro cell irradiations
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278697/
https://www.ncbi.nlm.nih.gov/pubmed/35847895
http://dx.doi.org/10.3389/fonc.2022.847090
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