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Peripheral artery disease affects the function of the legs of claudicating patients in a diffuse manner irrespective of the segment of the arterial tree primarily involved

Different levels of arterial occlusive disease (aortoiliac, femoropopliteal, multi-level disease) can produce claudication symptoms in different leg muscle groups (buttocks, thighs, calves) in patients with peripheral artery disease (PAD). We tested the hypothesis that different locations of occlusi...

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Autores principales: Leutzinger, Todd J., Koutakis, Panagiotis, Fuglestad, Matthew A., Rahman, Hafizur, Despiegelaere, Holly, Hassan, Mahdi, Schieber, Molly, Johanning, Jason M., Stergiou, Nick, Longo, G. Matthew, Casale, George P., Myers, Sara A., Pipinos, Iraklis I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278728/
https://www.ncbi.nlm.nih.gov/pubmed/35830421
http://dx.doi.org/10.1371/journal.pone.0264598
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author Leutzinger, Todd J.
Koutakis, Panagiotis
Fuglestad, Matthew A.
Rahman, Hafizur
Despiegelaere, Holly
Hassan, Mahdi
Schieber, Molly
Johanning, Jason M.
Stergiou, Nick
Longo, G. Matthew
Casale, George P.
Myers, Sara A.
Pipinos, Iraklis I.
author_facet Leutzinger, Todd J.
Koutakis, Panagiotis
Fuglestad, Matthew A.
Rahman, Hafizur
Despiegelaere, Holly
Hassan, Mahdi
Schieber, Molly
Johanning, Jason M.
Stergiou, Nick
Longo, G. Matthew
Casale, George P.
Myers, Sara A.
Pipinos, Iraklis I.
author_sort Leutzinger, Todd J.
collection PubMed
description Different levels of arterial occlusive disease (aortoiliac, femoropopliteal, multi-level disease) can produce claudication symptoms in different leg muscle groups (buttocks, thighs, calves) in patients with peripheral artery disease (PAD). We tested the hypothesis that different locations of occlusive disease uniquely affect the muscles of PAD legs and produce distinctive patterns in the way claudicating patients walk. Ninety-seven PAD patients and 35 healthy controls were recruited. PAD patients were categorized to aortoiliac, femoropopliteal and multi-level disease groups using computerized tomographic angiography. Subjects performed walking trials both pain-free and during claudication pain and joint kinematics, kinetics, and spatiotemporal parameters were calculated to evaluate the net contribution of the calf, thigh and buttock muscles. PAD patients with occlusive disease affecting different segments of the arterial tree (aortoiliac, femoropopliteal, multi-level disease) presented with symptoms affecting different muscle groups of the lower extremity (calves, thighs and buttocks alone or in combination). However, no significant biomechanical differences were found between PAD groups during the pain-free conditions with minimal differences between PAD groups in the claudicating state. All statistical differences in the pain-free condition occurred between healthy controls and one or more PAD groups. A discriminant analysis function was able to adequately predict if a subject was a control with over 70% accuracy, but the function was unable to differentiate between PAD groups. In-depth gait analyses of claudicating PAD patients indicate that different locations of arterial disease produce claudication symptoms that affect different muscle groups across the lower extremity but impact the function of the leg muscles in a diffuse manner generating similar walking impairments.
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spelling pubmed-92787282022-07-14 Peripheral artery disease affects the function of the legs of claudicating patients in a diffuse manner irrespective of the segment of the arterial tree primarily involved Leutzinger, Todd J. Koutakis, Panagiotis Fuglestad, Matthew A. Rahman, Hafizur Despiegelaere, Holly Hassan, Mahdi Schieber, Molly Johanning, Jason M. Stergiou, Nick Longo, G. Matthew Casale, George P. Myers, Sara A. Pipinos, Iraklis I. PLoS One Research Article Different levels of arterial occlusive disease (aortoiliac, femoropopliteal, multi-level disease) can produce claudication symptoms in different leg muscle groups (buttocks, thighs, calves) in patients with peripheral artery disease (PAD). We tested the hypothesis that different locations of occlusive disease uniquely affect the muscles of PAD legs and produce distinctive patterns in the way claudicating patients walk. Ninety-seven PAD patients and 35 healthy controls were recruited. PAD patients were categorized to aortoiliac, femoropopliteal and multi-level disease groups using computerized tomographic angiography. Subjects performed walking trials both pain-free and during claudication pain and joint kinematics, kinetics, and spatiotemporal parameters were calculated to evaluate the net contribution of the calf, thigh and buttock muscles. PAD patients with occlusive disease affecting different segments of the arterial tree (aortoiliac, femoropopliteal, multi-level disease) presented with symptoms affecting different muscle groups of the lower extremity (calves, thighs and buttocks alone or in combination). However, no significant biomechanical differences were found between PAD groups during the pain-free conditions with minimal differences between PAD groups in the claudicating state. All statistical differences in the pain-free condition occurred between healthy controls and one or more PAD groups. A discriminant analysis function was able to adequately predict if a subject was a control with over 70% accuracy, but the function was unable to differentiate between PAD groups. In-depth gait analyses of claudicating PAD patients indicate that different locations of arterial disease produce claudication symptoms that affect different muscle groups across the lower extremity but impact the function of the leg muscles in a diffuse manner generating similar walking impairments. Public Library of Science 2022-07-13 /pmc/articles/PMC9278728/ /pubmed/35830421 http://dx.doi.org/10.1371/journal.pone.0264598 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Leutzinger, Todd J.
Koutakis, Panagiotis
Fuglestad, Matthew A.
Rahman, Hafizur
Despiegelaere, Holly
Hassan, Mahdi
Schieber, Molly
Johanning, Jason M.
Stergiou, Nick
Longo, G. Matthew
Casale, George P.
Myers, Sara A.
Pipinos, Iraklis I.
Peripheral artery disease affects the function of the legs of claudicating patients in a diffuse manner irrespective of the segment of the arterial tree primarily involved
title Peripheral artery disease affects the function of the legs of claudicating patients in a diffuse manner irrespective of the segment of the arterial tree primarily involved
title_full Peripheral artery disease affects the function of the legs of claudicating patients in a diffuse manner irrespective of the segment of the arterial tree primarily involved
title_fullStr Peripheral artery disease affects the function of the legs of claudicating patients in a diffuse manner irrespective of the segment of the arterial tree primarily involved
title_full_unstemmed Peripheral artery disease affects the function of the legs of claudicating patients in a diffuse manner irrespective of the segment of the arterial tree primarily involved
title_short Peripheral artery disease affects the function of the legs of claudicating patients in a diffuse manner irrespective of the segment of the arterial tree primarily involved
title_sort peripheral artery disease affects the function of the legs of claudicating patients in a diffuse manner irrespective of the segment of the arterial tree primarily involved
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278728/
https://www.ncbi.nlm.nih.gov/pubmed/35830421
http://dx.doi.org/10.1371/journal.pone.0264598
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