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The two-domain elevator-type mechanism of zinc-transporting ZIP proteins

Zinc is essential for all organisms and yet detrimental at elevated levels. Hence, homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the only zinc importers in metazoans. Mutations in human ZIPs cause serious disorders, but the mechanism by which ZIPs transfe...

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Detalles Bibliográficos
Autores principales: Wiuf, Anders, Steffen, Jonas Hyld, Becares, Eva Ramos, Grønberg, Christina, Mahato, Dhani Ram, Rasmussen, Søren G. F., Andersson, Magnus, Croll, Tristan, Gotfryd, Kamil, Gourdon, Pontus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278863/
https://www.ncbi.nlm.nih.gov/pubmed/35857505
http://dx.doi.org/10.1126/sciadv.abn4331