Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

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Soluble angiotensin-converting enzyme 2 (ACE2) constitutes an attractive antiviral capable of targeting a wide range of coronaviruses using ACE2 as their receptor. Using structure-guided approaches, we developed a series of bivalent ACE2-Fcs harboring functionally and structurally validated mutation...

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Detalles Bibliográficos
Autores principales: Chen, Yaozong, Sun, Lulu, Ullah, Irfan, Beaudoin-Bussières, Guillaume, Anand, Sai Priya, Hederman, Andrew P., Tolbert, William D., Sherburn, Rebekah, Nguyen, Dung N., Marchitto, Lorie, Ding, Shilei, Wu, Di, Luo, Yuhong, Gottumukkala, Suneetha, Moran, Sean, Kumar, Priti, Piszczek, Grzegorz, Mothes, Walther, Ackerman, Margaret E., Finzi, Andrés, Uchil, Pradeep D., Gonzalez, Frank J., Pazgier, Marzena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278865/
https://www.ncbi.nlm.nih.gov/pubmed/35857504
http://dx.doi.org/10.1126/sciadv.abn4188
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