CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells

Genome-wide association studies (GWAS) have identified dozens of loci associated with chronic obstructive pulmonary disease (COPD) susceptibility; however, the function of associated genes in the cell type(s) affected in disease remains poorly understood, partly due to a lack of cell models that rec...

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Detalles Bibliográficos
Autores principales: Werder, Rhiannon B., Liu, Tao, Abo, Kristine M., Lindstrom-Vautrin, Jonathan, Villacorta-Martin, Carlos, Huang, Jessie, Hinds, Anne, Boyer, Nathan, Bullitt, Esther, Liesa, Marc, Silverman, Edwin K., Kotton, Darrell N., Cho, Michael H., Zhou, Xiaobo, Wilson, Andrew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278866/
https://www.ncbi.nlm.nih.gov/pubmed/35857525
http://dx.doi.org/10.1126/sciadv.abo6566

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