Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices

The transmembrane (TM) channel-like 1 (TMC1) and TMC2 proteins play a central role in auditory transduction, forming ion channels that convert sound into electrical signals. However, the molecular mechanism of their gating remains unknown. Here, using predicted structural models as a guide, we probe...

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Detalles Bibliográficos
Autores principales: Akyuz, Nurunisa, Karavitaki, K. Domenica, Pan, Bifeng, Tamvakologos, Panos I., Brock, Kelly P., Li, Yaqiao, Marks, Debora S., Corey, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278870/
https://www.ncbi.nlm.nih.gov/pubmed/35857511
http://dx.doi.org/10.1126/sciadv.abo1126

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