Biophysical K(v)3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s

In Alzheimer’s disease (AD), a multitude of genetic risk factors and early biomarkers are known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD remain controversial. Toxic plaques and tangles correlate with progressive neuropathology, yet disruptions in circuit a...

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Detalles Bibliográficos
Autores principales: Olah, Viktor J, Goettemoeller, Annie M, Rayaprolu, Sruti, Dammer, Eric B, Seyfried, Nicholas T, Rangaraju, Srikant, Dimidschstein, Jordane, Rowan, Matthew JM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278953/
https://www.ncbi.nlm.nih.gov/pubmed/35727131
http://dx.doi.org/10.7554/eLife.75316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278953/
https://www.ncbi.nlm.nih.gov/pubmed/35727131
http://dx.doi.org/10.7554/eLife.75316

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