TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway

Tumor metastasis is a fundamental cause of the poor prognosis of gastric carcinoma (GC). In order to study the problems affecting metastasis and recurrence of gastric cancer, the paper expose that TNF alpha induced protein 6 (TNFAIP6) is aberrantly overexpressed in GC, and patients with high-TNFAIP6...

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Detalles Bibliográficos
Autores principales: Cui, Hongquan, Zhang, Ling, Chen, Bin, Zhang, Fengchun, Xu, Haiyan, Ma, Guixiang, Cao, Longnv, Wang, Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279067/
https://www.ncbi.nlm.nih.gov/pubmed/35854776
http://dx.doi.org/10.1155/2022/5697034
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author Cui, Hongquan
Zhang, Ling
Chen, Bin
Zhang, Fengchun
Xu, Haiyan
Ma, Guixiang
Cao, Longnv
Wang, Miao
author_facet Cui, Hongquan
Zhang, Ling
Chen, Bin
Zhang, Fengchun
Xu, Haiyan
Ma, Guixiang
Cao, Longnv
Wang, Miao
author_sort Cui, Hongquan
collection PubMed
description Tumor metastasis is a fundamental cause of the poor prognosis of gastric carcinoma (GC). In order to study the problems affecting metastasis and recurrence of gastric cancer, the paper expose that TNF alpha induced protein 6 (TNFAIP6) is aberrantly overexpressed in GC, and patients with high-TNFAIP6 levels exhibited inferior overall survival. Mechanistically, overexpression of TNFAIP6 raised β-catenin ectopic nuclear distribution and activated the Wnt/β-catenin signal pathway. The experimental results show that TNFAIP6 facilitates the aggressive potential of GC cells through modulating PTX3 expression.
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spelling pubmed-92790672022-07-18 TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway Cui, Hongquan Zhang, Ling Chen, Bin Zhang, Fengchun Xu, Haiyan Ma, Guixiang Cao, Longnv Wang, Miao Contrast Media Mol Imaging Research Article Tumor metastasis is a fundamental cause of the poor prognosis of gastric carcinoma (GC). In order to study the problems affecting metastasis and recurrence of gastric cancer, the paper expose that TNF alpha induced protein 6 (TNFAIP6) is aberrantly overexpressed in GC, and patients with high-TNFAIP6 levels exhibited inferior overall survival. Mechanistically, overexpression of TNFAIP6 raised β-catenin ectopic nuclear distribution and activated the Wnt/β-catenin signal pathway. The experimental results show that TNFAIP6 facilitates the aggressive potential of GC cells through modulating PTX3 expression. Hindawi 2022-07-06 /pmc/articles/PMC9279067/ /pubmed/35854776 http://dx.doi.org/10.1155/2022/5697034 Text en Copyright © 2022 Hongquan Cui et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cui, Hongquan
Zhang, Ling
Chen, Bin
Zhang, Fengchun
Xu, Haiyan
Ma, Guixiang
Cao, Longnv
Wang, Miao
TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway
title TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway
title_full TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway
title_fullStr TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway
title_full_unstemmed TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway
title_short TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway
title_sort tnfaip6 promotes gastric carcinoma cell invasion via upregulating ptx3 and activating the wnt/β-catenin signaling pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279067/
https://www.ncbi.nlm.nih.gov/pubmed/35854776
http://dx.doi.org/10.1155/2022/5697034
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