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Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer
Emerging evidence shows a striking link between periodontal diseases and various human cancers including oral cancer. And periodontal pathogens, leading to periodontal diseases development, may serve a crucial role in oral cancer. This review elucidated the molecular mechanisms of periodontal pathog...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279119/ https://www.ncbi.nlm.nih.gov/pubmed/35847109 http://dx.doi.org/10.3389/fmicb.2022.919633 |
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author | Li, Tian-Jiao Hao, Yi-hang Tang, Ya-ling Liang, Xin-hua |
author_facet | Li, Tian-Jiao Hao, Yi-hang Tang, Ya-ling Liang, Xin-hua |
author_sort | Li, Tian-Jiao |
collection | PubMed |
description | Emerging evidence shows a striking link between periodontal diseases and various human cancers including oral cancer. And periodontal pathogens, leading to periodontal diseases development, may serve a crucial role in oral cancer. This review elucidated the molecular mechanisms of periodontal pathogens in oral cancer. The pathogens directly engage in their own unique molecular dialogue with the host epithelium to acquire cancer phenotypes, and indirectly induce a proinflammatory environment and carcinogenic substance in favor of cancer development. And functional, rather than compositional, properties of oral microbial community correlated with cancer development are discussed. The effect of periodontal pathogens on periodontal diseases and oral cancer will further detail the pathogenesis of oral cancer and intensify the need of maintaining oral hygiene for the prevention of oral diseases including oral cancer. |
format | Online Article Text |
id | pubmed-9279119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92791192022-07-14 Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer Li, Tian-Jiao Hao, Yi-hang Tang, Ya-ling Liang, Xin-hua Front Microbiol Microbiology Emerging evidence shows a striking link between periodontal diseases and various human cancers including oral cancer. And periodontal pathogens, leading to periodontal diseases development, may serve a crucial role in oral cancer. This review elucidated the molecular mechanisms of periodontal pathogens in oral cancer. The pathogens directly engage in their own unique molecular dialogue with the host epithelium to acquire cancer phenotypes, and indirectly induce a proinflammatory environment and carcinogenic substance in favor of cancer development. And functional, rather than compositional, properties of oral microbial community correlated with cancer development are discussed. The effect of periodontal pathogens on periodontal diseases and oral cancer will further detail the pathogenesis of oral cancer and intensify the need of maintaining oral hygiene for the prevention of oral diseases including oral cancer. Frontiers Media S.A. 2022-06-30 /pmc/articles/PMC9279119/ /pubmed/35847109 http://dx.doi.org/10.3389/fmicb.2022.919633 Text en Copyright © 2022 Li, Hao, Tang and Liang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Li, Tian-Jiao Hao, Yi-hang Tang, Ya-ling Liang, Xin-hua Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
title | Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
title_full | Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
title_fullStr | Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
title_full_unstemmed | Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
title_short | Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
title_sort | periodontal pathogens: a crucial link between periodontal diseases and oral cancer |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279119/ https://www.ncbi.nlm.nih.gov/pubmed/35847109 http://dx.doi.org/10.3389/fmicb.2022.919633 |
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