Cargando…

Effect of theobromine on dissolution of uric acid kidney stones

PURPOSE: Uric acid renal lithiasis has a high prevalence and a high rate of recurrence. Removal of uric acid stones can be achieved by several surgical techniques (extracorporeal shock wave lithotripsy, endoscopy, laparoscopy, open surgery). These stones can also be eliminated by dissolution within...

Descripción completa

Detalles Bibliográficos
Autores principales: Julià, Francesca, Costa-Bauza, Antonia, Berga, Francisco, Grases, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279199/
https://www.ncbi.nlm.nih.gov/pubmed/35689678
http://dx.doi.org/10.1007/s00345-022-04059-3
_version_ 1784746342127501312
author Julià, Francesca
Costa-Bauza, Antonia
Berga, Francisco
Grases, Felix
author_facet Julià, Francesca
Costa-Bauza, Antonia
Berga, Francisco
Grases, Felix
author_sort Julià, Francesca
collection PubMed
description PURPOSE: Uric acid renal lithiasis has a high prevalence and a high rate of recurrence. Removal of uric acid stones can be achieved by several surgical techniques (extracorporeal shock wave lithotripsy, endoscopy, laparoscopy, open surgery). These stones can also be eliminated by dissolution within the kidneys, because the solubility of uric acid is much greater when the pH is above 6. At present, N-acetylcysteine with a urinary basifying agent is the only treatment proposed to increase the dissolution of uric acid stones. In this paper, we compare the effect of theobromine and N-acetylcysteine on the in vitro dissolution of uric acid calculi in artificial urine at pH 6.5. METHODS: The dissolution of uric acid renal calculi was performed in a temperature-controlled (37 °C) chamber. A peristaltic pump was used to pass 750 mL of synthetic urine (pH 6.5) through a capsule every 24 h. Stone dissolution was evaluated by measuring the change in weight before and after each experiment. RESULTS: N-acetylcysteine increased the dissolution of uric acid calculi, but the effect was not statistically significant. Theobromine significantly increased the dissolution of uric acid calculi. Both substances together had the same effect as theobromine alone. The addition of theobromine to a basifying therapy that uses citrate and/or bicarbonate is a potential new strategy for the oral chemolysis of uric acid stones. CONCLUSION: Theobromine may prevent the formation of new stones and increase the dissolution of existing stones.
format Online
Article
Text
id pubmed-9279199
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-92791992022-07-15 Effect of theobromine on dissolution of uric acid kidney stones Julià, Francesca Costa-Bauza, Antonia Berga, Francisco Grases, Felix World J Urol Original Article PURPOSE: Uric acid renal lithiasis has a high prevalence and a high rate of recurrence. Removal of uric acid stones can be achieved by several surgical techniques (extracorporeal shock wave lithotripsy, endoscopy, laparoscopy, open surgery). These stones can also be eliminated by dissolution within the kidneys, because the solubility of uric acid is much greater when the pH is above 6. At present, N-acetylcysteine with a urinary basifying agent is the only treatment proposed to increase the dissolution of uric acid stones. In this paper, we compare the effect of theobromine and N-acetylcysteine on the in vitro dissolution of uric acid calculi in artificial urine at pH 6.5. METHODS: The dissolution of uric acid renal calculi was performed in a temperature-controlled (37 °C) chamber. A peristaltic pump was used to pass 750 mL of synthetic urine (pH 6.5) through a capsule every 24 h. Stone dissolution was evaluated by measuring the change in weight before and after each experiment. RESULTS: N-acetylcysteine increased the dissolution of uric acid calculi, but the effect was not statistically significant. Theobromine significantly increased the dissolution of uric acid calculi. Both substances together had the same effect as theobromine alone. The addition of theobromine to a basifying therapy that uses citrate and/or bicarbonate is a potential new strategy for the oral chemolysis of uric acid stones. CONCLUSION: Theobromine may prevent the formation of new stones and increase the dissolution of existing stones. Springer Berlin Heidelberg 2022-06-11 2022 /pmc/articles/PMC9279199/ /pubmed/35689678 http://dx.doi.org/10.1007/s00345-022-04059-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Julià, Francesca
Costa-Bauza, Antonia
Berga, Francisco
Grases, Felix
Effect of theobromine on dissolution of uric acid kidney stones
title Effect of theobromine on dissolution of uric acid kidney stones
title_full Effect of theobromine on dissolution of uric acid kidney stones
title_fullStr Effect of theobromine on dissolution of uric acid kidney stones
title_full_unstemmed Effect of theobromine on dissolution of uric acid kidney stones
title_short Effect of theobromine on dissolution of uric acid kidney stones
title_sort effect of theobromine on dissolution of uric acid kidney stones
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279199/
https://www.ncbi.nlm.nih.gov/pubmed/35689678
http://dx.doi.org/10.1007/s00345-022-04059-3
work_keys_str_mv AT juliafrancesca effectoftheobromineondissolutionofuricacidkidneystones
AT costabauzaantonia effectoftheobromineondissolutionofuricacidkidneystones
AT bergafrancisco effectoftheobromineondissolutionofuricacidkidneystones
AT grasesfelix effectoftheobromineondissolutionofuricacidkidneystones