Cargando…

Human myelin proteolipid protein structure and lipid bilayer stacking

The myelin sheath is an essential, multilayered membrane structure that insulates axons, enabling the rapid transmission of nerve impulses. The tetraspan myelin proteolipid protein (PLP) is the most abundant protein of compact myelin in the central nervous system (CNS). The integral membrane protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruskamo, Salla, Raasakka, Arne, Pedersen, Jan Skov, Martel, Anne, Škubník, Karel, Darwish, Tamim, Porcar, Lionel, Kursula, Petri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279222/ https://www.ncbi.nlm.nih.gov/pubmed/35829923 http://dx.doi.org/10.1007/s00018-022-04428-6

Ejemplares similares

Molecular structure and function of myelin protein P0 in membrane stacking
por: Raasakka, Arne, et al.
Publicado: (2019)

Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line
por: Raasakka, Arne, et al.
Publicado: (2017)

How Does Protein Zero Assemble Compact Myelin?
por: Raasakka, Arne, et al.
Publicado: (2020)

Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease
por: Raasakka, Arne, et al.
Publicado: (2020)

Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2
por: Ruskamo, Salla, et al.
Publicado: (2017)

Publisher Correction: Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2
por: Ruskamo, Salla, et al.
Publicado: (2018)

Correction: Raasakka, A.; Kursula, P. Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease. Cells 2020, 9, 470
por: Raasakka, Arne, et al.
Publicado: (2022)

Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins
por: Laulumaa, Saara, et al.
Publicado: (2018)

Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase
por: Muruganandam, Gopinath, et al.
Publicado: (2017)

The intrinsically disordered protein glue of the myelin major dense line: Linking AlphaFold2 predictions to experimental data
por: Krokengen, Oda C., et al.
Publicado: (2023)

Myelin 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation
por: Myllykoski, Matti, et al.
Publicado: (2012)

Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail
por: Raasakka, Arne, et al.
Publicado: (2019)

Determinants of ligand binding and catalytic activity in the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase
por: Raasakka, Arne, et al.
Publicado: (2015)

Structural insights into Charcot–Marie–Tooth disease‐linked mutations in human GDAP1
por: Sutinen, Aleksi, et al.
Publicado: (2022)

Atomic resolution view into the structure–function relationships of the human myelin peripheral membrane protein P2
por: Ruskamo, Salla, et al.
Publicado: (2013)

Stability and flexibility of full-length human oligodendrocytic QKI6
por: Raasakka, Arne, et al.
Publicado: (2019)

Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease
por: Simons, Mikael, et al.
Publicado: (2002)

Autoimmune T-Cell Reactivity to Myelin Proteolipids and Glycolipids in Multiple Sclerosis
por: Greer, Judith M.
Publicado: (2013)

Analogous amino acid sequences in myelin proteolipid and viral proteins
por: Shaw, Shyh-Yu, et al.
Publicado: (1986)

Juxtanodin is an intrinsically disordered F-actin-binding protein
por: Ruskamo, Salla, et al.
Publicado: (2012)

Ethanol down regulates the expression of myelin proteolipid protein in the rat hippocampus
por: Lee, Dong Hoon, et al.
Publicado: (2010)

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin
por: Snaidero, Nicolas, et al.
Publicado: (2017)

Assembly of Myelin by Association of Proteolipid Protein with Cholesterol- and Galactosylceramide-Rich Membrane Domains
por: Simons, Mikael, et al.
Publicado: (2000)

Crystallographic Analysis of the Reaction Cycle of 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family
por: Myllykoski, Matti, et al.
Publicado: (2013)

Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability
por: Sutinen, Aleksi, et al.
Publicado: (2023)

The initial events in myelin synthesis: orientation of proteolipid protein in the plasma membrane of cultured oligodendrocytes
Publicado: (1989)

A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice
Publicado: (1993)

Super-swelling behavior of stacked lipid bilayer systems
por: Rueben, Jacob, et al.
Publicado: (2023)

Proteolipid protein–deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling
por: Yin, Xinghua, et al.
Publicado: (2016)

T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis
por: Perry, Linda L., et al.
Publicado: (1991)

Multiple sclerosis and myelin basic protein: insights into protein disorder and disease
por: Martinsen, Vebjørn, et al.
Publicado: (2021)

Structure of the mouse acidic amino acid decarboxylase GADL1
por: Raasakka, Arne, et al.
Publicado: (2018)

Direct Binding of the Flexible C-Terminal Segment of Periaxin to β4 Integrin Suggests a Molecular Basis for CMT4F
por: Raasakka, Arne, et al.
Publicado: (2019)

Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein
por: Boyden, Alexander W., et al.
Publicado: (2020)

Crystallographic anomalous diffraction data for the experimental phasing of two myelin proteins, gliomedin and periaxin
por: Han, Huijong, et al.
Publicado: (2017)

YY1 negatively regulates mouse myelin proteolipid protein (Plp1) gene expression in oligodendroglial cells
por: Zolova, Olga E, et al.
Publicado: (2011)

Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1–anchored membrane domains
por: Owens, Gregory P., et al.
Publicado: (2023)

Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations
por: Nguyen, Giang Thi Tuyet, et al.
Publicado: (2021)

Erratum: Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights Into Ligand Binding and Clustering of Disease Mutations
por: Tuyet Nguyen, Giang Thi, et al.
Publicado: (2022)

Anti-Myelin Proteolipid Protein Peptide Monoclonal Antibodies Recognize Cell Surface Proteins on Developing Neurons and Inhibit Their Differentiation
por: Sobel, Raymond A, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6p5ktl6bd2o8vg6ia3l9qftgp6