Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR

Autophagy is a biological process that maintains cellular homeostasis and regulates the internal cellular environment. Hyperactivating autophagy to trigger cell death has been a suggested therapeutic strategy for cancer treatment. Mechanistic target of rapamycin (mTOR) is a crucial protein kinase th...

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Detalles Bibliográficos
Autores principales: Lee, Boah, Park, Seung Ju, Lee, Seulgi, Lee, Jinwook, Lee, Eunbeol, Yoo, Eun-Seon, Chung, Won-Suk, Sohn, Jong-Woo, Oh, Byung-Chul, Kim, Seyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279289/
https://www.ncbi.nlm.nih.gov/pubmed/35831271
http://dx.doi.org/10.1038/s41419-022-05039-6

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