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Targeting sphingosine kinase 1/2 by a novel dual inhibitor SKI-349 suppresses non-small cell lung cancer cell growth

Sphingosine kinase 1 (SphK1) and sphingosine kinase (SphK2) are both important therapeutic targets of non-small cell lung cancer (NSCLC). SKI-349 is a novel, highly efficient and small molecular SphK1/2 dual inhibitor. Here in primary human NSCLC cells and immortalized cell lines, SKI-349 potently i...

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Detalles Bibliográficos
Autores principales:	Xue, Yuhang, Jiang, Kanqiu, Ou, Li, Shen, Mingjing, Yang, Yi, Lu, Jingjing, Xu, Weihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279331/ https://www.ncbi.nlm.nih.gov/pubmed/35831279 http://dx.doi.org/10.1038/s41419-022-05049-4

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