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The mechanism for thermal-enhanced chaperone-like activity of α-crystallin against UV irradiation-induced aggregation of γD-crystallin

Exposure to solar UV irradiation damages γ-crystallin, leading to cataract formation via aggregation. α-Crystallin, as a small heat shock protein, efficiently suppresses this irreversible aggregation by selectively binding the denatured γ-crystallin monomer. In this study, liquid chromatography tand...

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Detalles Bibliográficos
Autores principales:	Li, Hao, Yu, Yingying, Ruan, Meixia, Jiao, Fang, Chen, Hailong, Gao, Jiali, Weng, Yuxiang, Bao, Yongzhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279354/ https://www.ncbi.nlm.nih.gov/pubmed/35619565 http://dx.doi.org/10.1016/j.bpj.2022.05.032

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