The shape of things to come: structural insights into how prion proteins encipher heritable information

The prion hypothesis embodies the radical concept that prion proteins contain the necessary information for infectious replication within their shape, thus obviating the requirement for genomic material. Two elegant papers by Hoyt et al. and Manka et al. describing high-resolution structures of infe...

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Autor principal: Telling, Glenn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279361/
https://www.ncbi.nlm.nih.gov/pubmed/35831278
http://dx.doi.org/10.1038/s41467-022-31460-8
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author Telling, Glenn C.
author_facet Telling, Glenn C.
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description The prion hypothesis embodies the radical concept that prion proteins contain the necessary information for infectious replication within their shape, thus obviating the requirement for genomic material. Two elegant papers by Hoyt et al. and Manka et al. describing high-resolution structures of infectious prions bring us closer to answering the long-standing question of how different prion conformations produce heritably distinct diseases.
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spelling pubmed-92793612022-07-15 The shape of things to come: structural insights into how prion proteins encipher heritable information Telling, Glenn C. Nat Commun Comment The prion hypothesis embodies the radical concept that prion proteins contain the necessary information for infectious replication within their shape, thus obviating the requirement for genomic material. Two elegant papers by Hoyt et al. and Manka et al. describing high-resolution structures of infectious prions bring us closer to answering the long-standing question of how different prion conformations produce heritably distinct diseases. Nature Publishing Group UK 2022-07-13 /pmc/articles/PMC9279361/ /pubmed/35831278 http://dx.doi.org/10.1038/s41467-022-31460-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Telling, Glenn C.
The shape of things to come: structural insights into how prion proteins encipher heritable information
title The shape of things to come: structural insights into how prion proteins encipher heritable information
title_full The shape of things to come: structural insights into how prion proteins encipher heritable information
title_fullStr The shape of things to come: structural insights into how prion proteins encipher heritable information
title_full_unstemmed The shape of things to come: structural insights into how prion proteins encipher heritable information
title_short The shape of things to come: structural insights into how prion proteins encipher heritable information
title_sort shape of things to come: structural insights into how prion proteins encipher heritable information
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279361/
https://www.ncbi.nlm.nih.gov/pubmed/35831278
http://dx.doi.org/10.1038/s41467-022-31460-8
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