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Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains

Little is known about the structural basis of prion strains. Here we provide a high (3.0 Å) resolution cryo-electron microscopy-based structure of infectious brain-derived fibrils of the mouse anchorless RML scrapie strain which, like the recently determined hamster 263K strain, has a parallel in-re...

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Detalles Bibliográficos
Autores principales:	Hoyt, Forrest, Standke, Heidi G., Artikis, Efrosini, Schwartz, Cindi L., Hansen, Bryan, Li, Kunpeng, Hughson, Andrew G., Manca, Matteo, Thomas, Olivia R., Raymond, Gregory J., Race, Brent, Baron, Gerald S., Caughey, Byron, Kraus, Allison
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279418/ https://www.ncbi.nlm.nih.gov/pubmed/35831291 http://dx.doi.org/10.1038/s41467-022-30458-6

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