B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12

Immunotherapies have revolutionized the treatment of B-cell acute lymphoblastic leukemia (B-ALL), but the duration of responses is still sub-optimal. We sought to identify mechanisms of immune suppression in B-ALL and strategies to overcome them. Plasma collected from children with B-ALL with measur...

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Detalles Bibliográficos
Autores principales: Hunter, Rae, Imbach, Kathleen J., Zhou, Chengjing, Dougan, Jodi, Hamilton, Jamie A. G., Chen, Kevin Z., Do, Priscilla, Townsel, Ashley, Gibson, Greg, Dreaden, Erik C., Waller, Edmund K., Haynes, Karmella A., Henry, Curtis J., Porter, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279427/
https://www.ncbi.nlm.nih.gov/pubmed/35831470
http://dx.doi.org/10.1038/s41598-022-16152-z

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