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Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells

Luteinizing hormone (LH) stimulates the synthesis and secretion of the key steroid hormone estrogen, which subsequently promotes ovarian follicular growth and development. Therefore, the administration of exogenous LH to achieve superovulation (multiple ovulations) and an LH surge is commonly used a...

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Autores principales: Park, Se-Ra, Kim, Seong-Kwan, Kim, Soo-Rim, Park, Jeong-Ran, Lim, Soyi, Hong, In-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279474/
https://www.ncbi.nlm.nih.gov/pubmed/35831270
http://dx.doi.org/10.1038/s41419-022-05054-7
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author Park, Se-Ra
Kim, Seong-Kwan
Kim, Soo-Rim
Park, Jeong-Ran
Lim, Soyi
Hong, In-Sun
author_facet Park, Se-Ra
Kim, Seong-Kwan
Kim, Soo-Rim
Park, Jeong-Ran
Lim, Soyi
Hong, In-Sun
author_sort Park, Se-Ra
collection PubMed
description Luteinizing hormone (LH) stimulates the synthesis and secretion of the key steroid hormone estrogen, which subsequently promotes ovarian follicular growth and development. Therefore, the administration of exogenous LH to achieve superovulation (multiple ovulations) and an LH surge is commonly used as the most effective therapeutic option in a majority of in vitro fertilization (IVF) clinics. However, a relatively low pregnancy rate (between 20% and 35%) is one of the most challenging aspects of LH-based infertility treatment. Furthermore, the major cause of this low pregnancy rate in LH-based infertility treatment remains unidentified. Recent studies have shown that endometrial stem cell loss or deficiency can significantly decrease tissue regeneration ability during the menstrual cycle and reduce endometrial receptivity. In this context, we postulated that the low pregnancy rates following LH-based ovarian hyperactivation may be the result of the adverse effects of consecutive exogenous LH administration on endometrial stem cells. To the best of our knowledge, this study revealed for the first time that in addition to its previously reported roles in stimulating ovarian functions through the pituitary-gonadal axis, LH brings about the extragonadal suppression of various tissue regeneration-associated functions in endometrial stem cells, such as self-renewal, migration ability, multilineage differentiation potential, and pluripotency/stemness, by inhibiting pro-survival Akt and ERK1/2 signaling pathways in vitro and in vivo, and as a consequence, it decreases the endometrial receptivity.
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spelling pubmed-92794742022-07-15 Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells Park, Se-Ra Kim, Seong-Kwan Kim, Soo-Rim Park, Jeong-Ran Lim, Soyi Hong, In-Sun Cell Death Dis Article Luteinizing hormone (LH) stimulates the synthesis and secretion of the key steroid hormone estrogen, which subsequently promotes ovarian follicular growth and development. Therefore, the administration of exogenous LH to achieve superovulation (multiple ovulations) and an LH surge is commonly used as the most effective therapeutic option in a majority of in vitro fertilization (IVF) clinics. However, a relatively low pregnancy rate (between 20% and 35%) is one of the most challenging aspects of LH-based infertility treatment. Furthermore, the major cause of this low pregnancy rate in LH-based infertility treatment remains unidentified. Recent studies have shown that endometrial stem cell loss or deficiency can significantly decrease tissue regeneration ability during the menstrual cycle and reduce endometrial receptivity. In this context, we postulated that the low pregnancy rates following LH-based ovarian hyperactivation may be the result of the adverse effects of consecutive exogenous LH administration on endometrial stem cells. To the best of our knowledge, this study revealed for the first time that in addition to its previously reported roles in stimulating ovarian functions through the pituitary-gonadal axis, LH brings about the extragonadal suppression of various tissue regeneration-associated functions in endometrial stem cells, such as self-renewal, migration ability, multilineage differentiation potential, and pluripotency/stemness, by inhibiting pro-survival Akt and ERK1/2 signaling pathways in vitro and in vivo, and as a consequence, it decreases the endometrial receptivity. Nature Publishing Group UK 2022-07-13 /pmc/articles/PMC9279474/ /pubmed/35831270 http://dx.doi.org/10.1038/s41419-022-05054-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Park, Se-Ra
Kim, Seong-Kwan
Kim, Soo-Rim
Park, Jeong-Ran
Lim, Soyi
Hong, In-Sun
Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells
title Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells
title_full Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells
title_fullStr Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells
title_full_unstemmed Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells
title_short Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells
title_sort novel roles of luteinizing hormone (lh) in tissue regeneration-associated functions in endometrial stem cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279474/
https://www.ncbi.nlm.nih.gov/pubmed/35831270
http://dx.doi.org/10.1038/s41419-022-05054-7
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