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Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer

Point-mutations of MEK1, a central component of ERK signaling, are present in cancer and RASopathies, but their precise biological effects remain obscure. Here, we report a mutant MEK1 structure that uncovers the mechanisms underlying abnormal activities of cancer- and RASopathy-associated MEK1 muta...

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Detalles Bibliográficos
Autores principales:	Kubota, Yuji, Fujioka, Yuko, Patil, Ashwini, Takagi, Yusuke, Matsubara, Daisuke, Iijima, Masatomi, Momose, Isao, Naka, Ryosuke, Nakai, Kenta, Noda, Nobuo N., Takekawa, Mutsuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279491/ https://www.ncbi.nlm.nih.gov/pubmed/35831322 http://dx.doi.org/10.1038/s41467-022-31690-w

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