Cargando…

Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management

In recent years, immunotherapy has become an important pillar of cancer treatment, with high response rates regardless of tumor histology or baseline mutations, sometime in patients without any alternative of treatment. Moreover, these treatments are moving from later line therapies to front-line th...

Descripción completa

Detalles Bibliográficos
Autores principales: Robles-Alonso, Virginia, Martínez-Valle, Fernando, Borruel, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279607/
https://www.ncbi.nlm.nih.gov/pubmed/35847803
http://dx.doi.org/10.3389/fmed.2022.906098
_version_ 1784746435764289536
author Robles-Alonso, Virginia
Martínez-Valle, Fernando
Borruel, Natalia
author_facet Robles-Alonso, Virginia
Martínez-Valle, Fernando
Borruel, Natalia
author_sort Robles-Alonso, Virginia
collection PubMed
description In recent years, immunotherapy has become an important pillar of cancer treatment, with high response rates regardless of tumor histology or baseline mutations, sometime in patients without any alternative of treatment. Moreover, these treatments are moving from later line therapies to front-line therapies in the metastasic setting. However, immune activation associated with immune check-point inhibitors (ICI) is not selective and a large variety of immune-related adverse events, with an increasing frequency, have been associated with anti-PD1, anti-PD-1/L-1 and anti-CTLA-4 agents. In clinical trials, and sometimes also in real life practice, patients who develop severe toxicities on ICI-based therapies are usually not allowed to resume ICI once their disease progresses, because of the chance of developing severe irAEs on rechallenge with immunotherapies. Moreover, patients with irAEs suffer important side effects due to the high dose corticosteroids that are used to treat them. Therapy with ICI is sometimes the only alternative for certain patients, and for this reason co treatment with classic (DMARDS) or biologic immunosuppression therapy and ICI must be considered. Co-treatment with this type of immunosuppressant drugs, apart from allowing the maintenance of ICI therapy, drive to a lesser use of corticosteroids, with an improvement of the safety and quality of life of the patients. Such a tailored scheme of treatment is mostly an expert opinion based on recommendation and currently there is scarce evidence supporting it. Herein we present comprehensive, current recommendations and real-world data on the use of co-treatment with ICI and DMARDS and biologic immunosuppression.
format Online
Article
Text
id pubmed-9279607
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92796072022-07-15 Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management Robles-Alonso, Virginia Martínez-Valle, Fernando Borruel, Natalia Front Med (Lausanne) Medicine In recent years, immunotherapy has become an important pillar of cancer treatment, with high response rates regardless of tumor histology or baseline mutations, sometime in patients without any alternative of treatment. Moreover, these treatments are moving from later line therapies to front-line therapies in the metastasic setting. However, immune activation associated with immune check-point inhibitors (ICI) is not selective and a large variety of immune-related adverse events, with an increasing frequency, have been associated with anti-PD1, anti-PD-1/L-1 and anti-CTLA-4 agents. In clinical trials, and sometimes also in real life practice, patients who develop severe toxicities on ICI-based therapies are usually not allowed to resume ICI once their disease progresses, because of the chance of developing severe irAEs on rechallenge with immunotherapies. Moreover, patients with irAEs suffer important side effects due to the high dose corticosteroids that are used to treat them. Therapy with ICI is sometimes the only alternative for certain patients, and for this reason co treatment with classic (DMARDS) or biologic immunosuppression therapy and ICI must be considered. Co-treatment with this type of immunosuppressant drugs, apart from allowing the maintenance of ICI therapy, drive to a lesser use of corticosteroids, with an improvement of the safety and quality of life of the patients. Such a tailored scheme of treatment is mostly an expert opinion based on recommendation and currently there is scarce evidence supporting it. Herein we present comprehensive, current recommendations and real-world data on the use of co-treatment with ICI and DMARDS and biologic immunosuppression. Frontiers Media S.A. 2022-06-30 /pmc/articles/PMC9279607/ /pubmed/35847803 http://dx.doi.org/10.3389/fmed.2022.906098 Text en Copyright © 2022 Robles-Alonso, Martínez-Valle and Borruel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Robles-Alonso, Virginia
Martínez-Valle, Fernando
Borruel, Natalia
Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management
title Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management
title_full Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management
title_fullStr Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management
title_full_unstemmed Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management
title_short Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management
title_sort co treatment with biologic agents and immunotherapy in the setting of iraes of difficult management
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279607/
https://www.ncbi.nlm.nih.gov/pubmed/35847803
http://dx.doi.org/10.3389/fmed.2022.906098
work_keys_str_mv AT roblesalonsovirginia cotreatmentwithbiologicagentsandimmunotherapyinthesettingofiraesofdifficultmanagement
AT martinezvallefernando cotreatmentwithbiologicagentsandimmunotherapyinthesettingofiraesofdifficultmanagement
AT borruelnatalia cotreatmentwithbiologicagentsandimmunotherapyinthesettingofiraesofdifficultmanagement