Discovery of a highly specific (18)F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination

As a member of cyclic nucleotide phosphodiesterase (PDE) enzyme family, PDE10A is in charge of the degradation of cyclic adenosine (cAMP) and guanosine monophosphates (cGMP). While PDE10A is primarily expressed in the medium spiny neurons of the striatum, it has been implicated in a variety of neuro...

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Detalles Bibliográficos
Autores principales: Xiao, Zhiwei, Wei, Huiyi, Xu, Yi, Haider, Ahmed, Wei, Junjie, Yuan, Shiyu, Rong, Jian, Zhao, Chunyu, Li, Guocong, Zhang, Weibin, Chen, Huangcan, Li, Yuefeng, Zhang, Lingling, Sun, Jiyun, Zhang, Shaojuan, Luo, Hai-Bin, Yan, Sen, Cai, Qijun, Hou, Lu, Che, Chao, Liang, Steven H., Wang, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279629/
https://www.ncbi.nlm.nih.gov/pubmed/35847497
http://dx.doi.org/10.1016/j.apsb.2021.11.014

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