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Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury

The mechanism of sphingosine-1-phosphate (S1P)-mediated phagocytosis remains unknown. Here, we found that S1P or FTY720 (an analog of S1P) promoted microglial phagocytosis in stroke independent of S1PRs. First, we used computer simulation of molecular docking to predict that S1P might be a ligand fo...

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Detalles Bibliográficos
Autores principales:	Xue, Tengfei, Ji, Juan, Sun, Yuqin, Huang, Xinxin, Cai, Zhenyu, Yang, Jin, Guo, Wei, Guo, Ruobing, Cheng, Hong, Sun, Xiulan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279640/ https://www.ncbi.nlm.nih.gov/pubmed/35847502 http://dx.doi.org/10.1016/j.apsb.2021.10.012

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