Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ(42) toxicity

Mitochondria-ER contact sites (MERCs) orchestrate many important cellular functions including regulating mitochondrial quality control through mitophagy and mediating mitochondrial calcium uptake. Here, we identify and functionally characterize the Drosophila ortholog of the recently identified mamm...

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Detalles Bibliográficos
Autores principales: Hewitt, Victoria L, Miller-Fleming, Leonor, Twyning, Madeleine J, Andreazza, Simonetta, Mattedi, Francesca, Prudent, Julien, Polleux, Franck, Vagnoni, Alessio, Whitworth, Alexander J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279675/
https://www.ncbi.nlm.nih.gov/pubmed/35831024
http://dx.doi.org/10.26508/lsa.202201531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279675/
https://www.ncbi.nlm.nih.gov/pubmed/35831024
http://dx.doi.org/10.26508/lsa.202201531

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