ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1

Crosstalk between the Hedgehog and MAPK signaling pathways occurs in several types of cancer and contributes to clinical resistance to Hedgehog pathway inhibitors. Here we show that MAP kinase-mediated phosphorylation weakens the binding of the GLI1 transcription factor to its negative regulator SUF...

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Detalles Bibliográficos
Autores principales: Bardwell, A Jane, Wu, Beibei, Sarin, Kavita Y, Waterman, Marian L, Atwood, Scott X, Bardwell, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279676/
https://www.ncbi.nlm.nih.gov/pubmed/35831023
http://dx.doi.org/10.26508/lsa.202101353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279676/
https://www.ncbi.nlm.nih.gov/pubmed/35831023
http://dx.doi.org/10.26508/lsa.202101353

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