PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia

Mutations in the plant homeodomain-like finger protein 6 (PHF6) gene are strongly associated with acute myeloid (AML) and T-cell acute lymphoblastic leukemia (T-ALL). In this study, we demonstrated that PHF6 can bind to H3K9me3 and H3K27me1 on the nucleolar chromatin and recruit histone methyltransf...

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Detalles Bibliográficos
Autores principales: Tsai, Hsiang-i, Wu, Yanping, Huang, Rui, Su, Dandan, Wu, Yingyi, Liu, Xiaoyan, Wang, Linglu, Xu, Zhanxue, Pang, Yuxin, Sun, Chong, He, Chao, Shu, Fan, Zhu, Haitao, Wang, Dongqing, Cheng, Fang, Huang, Laiqiang, Chen, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279718/
https://www.ncbi.nlm.nih.gov/pubmed/35847518
http://dx.doi.org/10.1016/j.apsb.2021.10.025

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