Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV)

Current drugs for treating human cytomegalovirus (HCMV) infections are limited by resistance and treatment-associated toxicities. In developing mechanistically novel HCMV antivirals, we discovered an N-benzyl hydroxypyridone carboxamide antiviral hit (8a) inhibiting HCMV in submicromolar range. We d...

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Detalles Bibliográficos
Autores principales: Senaweera, Sameera, Edwards, Tiffany C., Kankanala, Jayakanth, Wang, Yan, Sahani, Rajkumar Lalji, Xie, Jiashu, Geraghty, Robert J., Wang, Zhengqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279720/
https://www.ncbi.nlm.nih.gov/pubmed/35847513
http://dx.doi.org/10.1016/j.apsb.2021.08.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279720/
https://www.ncbi.nlm.nih.gov/pubmed/35847513
http://dx.doi.org/10.1016/j.apsb.2021.08.019

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