Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

OBJECTIVES: To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. METHODS: We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and ~1 million controls from Northwestern Europe. We searched for...

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Detalles Bibliográficos
Autores principales: Saevarsdottir, Saedis, Stefansdottir, Lilja, Sulem, Patrick, Thorleifsson, Gudmar, Ferkingstad, Egil, Rutsdottir, Gudrun, Glintborg, Bente, Westerlind, Helga, Grondal, Gerdur, Loft, Isabella C, Sorensen, Signe Bek, Lie, Benedicte A, Brink, Mikael, Ärlestig, Lisbeth, Arnthorsson, Asgeir Orn, Baecklund, Eva, Banasik, Karina, Bank, Steffen, Bjorkman, Lena I, Ellingsen, Torkell, Erikstrup, Christian, Frei, Oleksandr, Gjertsson, Inger, Gudbjartsson, Daniel F, Gudjonsson, Sigurjon A, Halldorsson, Gisli H, Hendricks, Oliver, Hillert, Jan, Hogdall, Estrid, Jacobsen, Søren, Jensen, Dorte Vendelbo, Jonsson, Helgi, Kastbom, Alf, Kockum, Ingrid, Kristensen, Salome, Kristjansdottir, Helga, Larsen, Margit H, Linauskas, Asta, Hauge, Ellen-Margrethe, Loft, Anne G, Ludviksson, Bjorn R, Lund, Sigrun H, Markusson, Thorsteinn, Masson, Gisli, Melsted, Pall, Moore, Kristjan H S, Munk, Heidi, Nielsen, Kaspar R, Norddahl, Gudmundur L, Oddsson, Asmundur, Olafsdottir, Thorunn A, Olason, Pall I, Olsson, Tomas, Ostrowski, Sisse Rye, Hørslev-Petersen, Kim, Rognvaldsson, Solvi, Sanner, Helga, Silberberg, Gilad N, Stefansson, Hreinn, Sørensen, Erik, Sørensen, Inge J, Turesson, Carl, Bergman, Thomas, Alfredsson, Lars, Kvien, Tore K, Brunak, Søren, Steinsson, Kristján, Andersen, Vibeke, Andreassen, Ole A, Rantapää-Dahlqvist, Solbritt, Hetland, Merete Lund, Klareskog, Lars, Askling, Johan, Padyukov, Leonid, Pedersen, Ole BV, Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Stefansson, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Rheumatoid Arthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279832/
https://www.ncbi.nlm.nih.gov/pubmed/35470158
http://dx.doi.org/10.1136/annrheumdis-2021-221754

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