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Combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer

BACKGROUND: A growing number of studies have found a close association between thyroid hormones and thyrotrophin (TSH), and they also have prognostic significance in some cancer types; this study aimed to investigate the prognostic value of free triiodothyronine (fT3), free thyroxine (fT4), fT3/fT4,...

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Autores principales: Liu, Yushu, Huang, Yanyi, Mo, Guoheng, Zhou, Tao, Hou, Qian, Shi, Chaoqun, Yu, Jichun, Lv, Yunxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279971/
https://www.ncbi.nlm.nih.gov/pubmed/35666615
http://dx.doi.org/10.1002/jcla.24503
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author Liu, Yushu
Huang, Yanyi
Mo, Guoheng
Zhou, Tao
Hou, Qian
Shi, Chaoqun
Yu, Jichun
Lv, Yunxia
author_facet Liu, Yushu
Huang, Yanyi
Mo, Guoheng
Zhou, Tao
Hou, Qian
Shi, Chaoqun
Yu, Jichun
Lv, Yunxia
author_sort Liu, Yushu
collection PubMed
description BACKGROUND: A growing number of studies have found a close association between thyroid hormones and thyrotrophin (TSH), and they also have prognostic significance in some cancer types; this study aimed to investigate the prognostic value of free triiodothyronine (fT3), free thyroxine (fT4), fT3/fT4, TSH, and their combination in patients with papillary thyroid carcinoma (PTC). METHODS: This study retrospectively analyzed the relevant data of 726 newly diagnosed PTC patients. Both univariate and multivariate analyses were used to predict the recurrence rate, and a risk score was established. In addition, with the use of a random survival forest, a random forest (RF) score was constructed. After calculating the area under the curve (AUC), the diagnostic efficacy of risk score, RF score, and four indicators was compared. RESULTS: fT3, fT4, fT3/fT4, and TSH were strongly associated with some invasive clinicopathological features and postoperative recurrence. Patients with high expression of fT4 and TSH have a high risk of recurrence. By contrast, patients with high expression of fT3 and fT3/fT4 have a low risk of recurrence. At the same time, the combined use of various indicators is more helpful for establishing an accurate diagnosis. By comparison, we found that the RF score was better than the risk score in terms of predicting the recurrence of PTC. CONCLUSION: The diagnostic accuracy of a combination of fT3, fT4, fT3/fT4, and TSH can help improve our clinical estimate of the risk of recurrent PTC, thus allowing the development of a more effective treatment plan for patients.
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spelling pubmed-92799712022-07-15 Combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer Liu, Yushu Huang, Yanyi Mo, Guoheng Zhou, Tao Hou, Qian Shi, Chaoqun Yu, Jichun Lv, Yunxia J Clin Lab Anal Research Articles BACKGROUND: A growing number of studies have found a close association between thyroid hormones and thyrotrophin (TSH), and they also have prognostic significance in some cancer types; this study aimed to investigate the prognostic value of free triiodothyronine (fT3), free thyroxine (fT4), fT3/fT4, TSH, and their combination in patients with papillary thyroid carcinoma (PTC). METHODS: This study retrospectively analyzed the relevant data of 726 newly diagnosed PTC patients. Both univariate and multivariate analyses were used to predict the recurrence rate, and a risk score was established. In addition, with the use of a random survival forest, a random forest (RF) score was constructed. After calculating the area under the curve (AUC), the diagnostic efficacy of risk score, RF score, and four indicators was compared. RESULTS: fT3, fT4, fT3/fT4, and TSH were strongly associated with some invasive clinicopathological features and postoperative recurrence. Patients with high expression of fT4 and TSH have a high risk of recurrence. By contrast, patients with high expression of fT3 and fT3/fT4 have a low risk of recurrence. At the same time, the combined use of various indicators is more helpful for establishing an accurate diagnosis. By comparison, we found that the RF score was better than the risk score in terms of predicting the recurrence of PTC. CONCLUSION: The diagnostic accuracy of a combination of fT3, fT4, fT3/fT4, and TSH can help improve our clinical estimate of the risk of recurrent PTC, thus allowing the development of a more effective treatment plan for patients. John Wiley and Sons Inc. 2022-06-06 /pmc/articles/PMC9279971/ /pubmed/35666615 http://dx.doi.org/10.1002/jcla.24503 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Liu, Yushu
Huang, Yanyi
Mo, Guoheng
Zhou, Tao
Hou, Qian
Shi, Chaoqun
Yu, Jichun
Lv, Yunxia
Combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer
title Combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer
title_full Combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer
title_fullStr Combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer
title_full_unstemmed Combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer
title_short Combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer
title_sort combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279971/
https://www.ncbi.nlm.nih.gov/pubmed/35666615
http://dx.doi.org/10.1002/jcla.24503
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