Cargando…

Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells via Tryptophan 2,3 Dioxygenase

In addition to its well-established immunosuppressive actions, tryptophan 2,3-dioxygenase (TDO) appears to elicit direct effects on tumor cell function. Although TDO has been associated with cancer stemness, its involvement in melanoma stem cell biology remains largely unknown. Since we showed that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cecchi, Marta, Mannini, Antonella, Lapucci, Andrea, Silvano, Angela, Lulli, Matteo, Luceri, Cristina, D’Ambrosio, Mario, Chiarugi, Alberto, Eid, Ali H., Parenti, Astrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280025/ https://www.ncbi.nlm.nih.gov/pubmed/35847038 http://dx.doi.org/10.3389/fphar.2022.911019

Ejemplares similares

Dexamethasone Induces the Expression and Function of Tryptophan-2-3-Dioxygenase in SK-MEL-28 Melanoma Cells
por: Cecchi, Marta, et al.
Publicado: (2021)

Different effects of tryptophan 2,3-dioxygenase inhibition on SK-Mel-28 and HCT-8 cancer cell lines
por: Paccosi, Sara, et al.
Publicado: (2020)

Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma
por: Terai, Mizue, et al.
Publicado: (2020)

Exploring the mechanism of tryptophan 2,3-dioxygenase
por: Thackray, Sarah J., et al.
Publicado: (2008)

Editorial: Targeting Indoleamine 2,3-dioxygenases and Tryptophan Dioxygenase for Cancer Immunotherapy
por: Brochez, Lieve, et al.
Publicado: (2021)

A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases
por: Zhou, Qihui, et al.
Publicado: (2021)

Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function
por: Elbers, Frank, et al.
Publicado: (2016)

Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase
por: Yoshioka, Saeko, et al.
Publicado: (2022)

Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice
por: Maeta, Akihiro, et al.
Publicado: (2013)

Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer
por: Chen, I-Chien, et al.
Publicado: (2016)

Influence of Tryptophan Contained in 1-Methyl-Tryptophan on Antimicrobial and Immunoregulatory Functions of Indoleamine 2,3-Dioxygenase
por: Schmidt, Silvia K., et al.
Publicado: (2012)

The Plasma [Kynurenine]/[Tryptophan] Ratio and Indoleamine 2,3-Dioxygenase: Time for Appraisal
por: Badawy, Abdulla A-B, et al.
Publicado: (2019)

Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepG2 Tumor Cells
por: Oweira, Hani, et al.
Publicado: (2022)

Modulation of Tryptophan Metabolism, Pomotion of Neurogenesis and Alteration of Anxiety-Related Behavior in Tryptophan 2,3-Dioxygenase-Deficient Mice
por: Funakoshi, Hiroshi, et al.
Publicado: (2011)

The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance
por: Hestad, Knut A., et al.
Publicado: (2017)

Comprehensive behavioral analysis of tryptophan 2,3‐dioxygenase (Tdo2) knockout mice
por: Hattori, Satoko, et al.
Publicado: (2018)

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening
por: Sari, Suat, et al.
Publicado: (2019)

Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening
por: Zhang, Guoqing, et al.
Publicado: (2018)

Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus
por: Ohira,, Koji, et al.
Publicado: (2010)

Probing the Ternary Complexes of Indoleamine and Tryptophan 2,3-Dioxygenases by Cryoreduction EPR and ENDOR Spectroscopy
por: Davydov, Roman M., et al.
Publicado: (2010)

Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase
por: Lewis-Ballester, Ariel, et al.
Publicado: (2016)

Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
por: Reed, Megan R, et al.
Publicado: (2021)

Tryptophan 2,3‐dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma
por: Sumitomo, Makoto, et al.
Publicado: (2021)

Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status
por: Hutchinson, Anne P., et al.
Publicado: (2022)

Association of Microbial Tryptophan Metabolites and Indoleamine-2,3-Dioxygenase with Immune Activity in Healthy Adults
por: Riazati, Niknaz, et al.
Publicado: (2022)

Enhanced tryptophan-kynurenine metabolism via indoleamine 2,3-dioxygenase 1 induction in dermatomyositis
por: Wu, Dan, et al.
Publicado: (2022)

Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges
por: Peng, Xuerun, et al.
Publicado: (2022)

Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl(4)-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation
por: Zhong, Weichao, et al.
Publicado: (2017)

Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice
por: Szántó, Sándor, et al.
Publicado: (2007)

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
por: Kanai, Masaaki, et al.
Publicado: (2009)

Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase
por: Michels, Helen, et al.
Publicado: (2016)

Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma
por: Mohapatra, Soumya R., et al.
Publicado: (2019)

Correction to: Enhanced tryptophan-kynurenine metabolism via indoleamine 2,3-dioxygenase 1 induction in dermatomyositis
por: Wu, Dan, et al.
Publicado: (2022)

Associations of microbial and indoleamine-2,3-dioxygenase-derived tryptophan metabolites with immune activation in healthy adults
por: Riazati, Niknaz, et al.
Publicado: (2022)

The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression
por: Nguyen, Dustin T., et al.
Publicado: (2023)

The Effect of Tryptophan 2,3-Dioxygenase Inhibition on Kynurenine Metabolism and Cognitive Function in the APP23 Mouse Model of Alzheimer’s Disease
por: Sorgdrager, FJH, et al.
Publicado: (2020)

The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase
por: Mudhish, Ethar A., et al.
Publicado: (2022)

Indoleamine 2,3-dioxygenase 1 promotes osteosarcoma progression by regulating tumor-derived exosomal miRNA hsa-miR-23a-3p
por: Yang, Dan, et al.
Publicado: (2023)

Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase
por: Frumento, Guido, et al.
Publicado: (2002)

Implication of Tryptophan 2,3-Dioxygenase and its Novel Variants in the Hippocampus and Cerebellum During the Developing and Adult Brain
por: Kanai, Masaaki, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_uu1kl8str4hqncf1ne0j86c1tv