Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis

Ferroptosis was induced the programmed cell death with iron overload Fenton reaction. Currently, ferroptosis has not been studied thoroughly. Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelat...

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Autores principales: Yan, Chunlu, Zhang, Jinlong, An, Fangyu, Wang, Jiayu, Shi, Yao, Yuan, Lingqing, Lv, Donghui, Zhao, Yanzhen, Wang, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Public Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280046/
https://www.ncbi.nlm.nih.gov/pubmed/35844870
http://dx.doi.org/10.3389/fpubh.2022.910675
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author Yan, Chunlu
Zhang, Jinlong
An, Fangyu
Wang, Jiayu
Shi, Yao
Yuan, Lingqing
Lv, Donghui
Zhao, Yanzhen
Wang, Yongfeng
author_facet Yan, Chunlu
Zhang, Jinlong
An, Fangyu
Wang, Jiayu
Shi, Yao
Yuan, Lingqing
Lv, Donghui
Zhao, Yanzhen
Wang, Yongfeng
author_sort Yan, Chunlu
collection PubMed
description Ferroptosis was induced the programmed cell death with iron overload Fenton reaction. Currently, ferroptosis has not been studied thoroughly. Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. Other evidence supports that ferroptosis is participated osteoporotic bone remodeling, predominantly affecting the interaction between bone formation and bone resorption, explicitly bone resorption exceeded bone formation. Based on previous studies, this review will summarize the regulatory network mechanism of ferroptosis on bone remodeling and reveal the role of ferroptosis in osteoporosis (OP).
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spelling pubmed-92800462022-07-15 Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis Yan, Chunlu Zhang, Jinlong An, Fangyu Wang, Jiayu Shi, Yao Yuan, Lingqing Lv, Donghui Zhao, Yanzhen Wang, Yongfeng Front Public Health Public Health Ferroptosis was induced the programmed cell death with iron overload Fenton reaction. Currently, ferroptosis has not been studied thoroughly. Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. Other evidence supports that ferroptosis is participated osteoporotic bone remodeling, predominantly affecting the interaction between bone formation and bone resorption, explicitly bone resorption exceeded bone formation. Based on previous studies, this review will summarize the regulatory network mechanism of ferroptosis on bone remodeling and reveal the role of ferroptosis in osteoporosis (OP). Frontiers Media S.A. 2022-06-30 /pmc/articles/PMC9280046/ /pubmed/35844870 http://dx.doi.org/10.3389/fpubh.2022.910675 Text en Copyright © 2022 Yan, Zhang, An, Wang, Shi, Yuan, Lv, Zhao and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Yan, Chunlu
Zhang, Jinlong
An, Fangyu
Wang, Jiayu
Shi, Yao
Yuan, Lingqing
Lv, Donghui
Zhao, Yanzhen
Wang, Yongfeng
Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis
title Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis
title_full Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis
title_fullStr Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis
title_full_unstemmed Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis
title_short Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis
title_sort research progress of ferroptosis regulatory network and bone remodeling in osteoporosis
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280046/
https://www.ncbi.nlm.nih.gov/pubmed/35844870
http://dx.doi.org/10.3389/fpubh.2022.910675
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