Use of Everolimus to treat cardiac rhabdomyomas and incessant arrhythmias in a newborn: Benefits and complications

We report treating a term neonate with tuberous sclerosis and giant rhabdomyomas who presented with incessant supraventricular tachycardia with Everolimus. The treatment was efficient in reducing tumor size and assisted as an adjunct therapy in controlling arrhythmia and limiting preexcitation. Trea...

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Autores principales: Sagiv, Eyal, Chikkabyrappa, Sathish Mallenahalli, Conwell, Jeffrey, Lewin, Mark, Chun, Terrence Un Hoong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280109/
https://www.ncbi.nlm.nih.gov/pubmed/35847399
http://dx.doi.org/10.4103/apc.apc_11_21
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author Sagiv, Eyal
Chikkabyrappa, Sathish Mallenahalli
Conwell, Jeffrey
Lewin, Mark
Chun, Terrence Un Hoong
author_facet Sagiv, Eyal
Chikkabyrappa, Sathish Mallenahalli
Conwell, Jeffrey
Lewin, Mark
Chun, Terrence Un Hoong
author_sort Sagiv, Eyal
collection PubMed
description We report treating a term neonate with tuberous sclerosis and giant rhabdomyomas who presented with incessant supraventricular tachycardia with Everolimus. The treatment was efficient in reducing tumor size and assisted as an adjunct therapy in controlling arrhythmia and limiting preexcitation. Treatment was challenged by difficulty to achieve stable drug level and limited by neutropenia as a serious side effect.
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spelling pubmed-92801092022-07-15 Use of Everolimus to treat cardiac rhabdomyomas and incessant arrhythmias in a newborn: Benefits and complications Sagiv, Eyal Chikkabyrappa, Sathish Mallenahalli Conwell, Jeffrey Lewin, Mark Chun, Terrence Un Hoong Ann Pediatr Cardiol Case Report We report treating a term neonate with tuberous sclerosis and giant rhabdomyomas who presented with incessant supraventricular tachycardia with Everolimus. The treatment was efficient in reducing tumor size and assisted as an adjunct therapy in controlling arrhythmia and limiting preexcitation. Treatment was challenged by difficulty to achieve stable drug level and limited by neutropenia as a serious side effect. Wolters Kluwer - Medknow 2022 2022-06-14 /pmc/articles/PMC9280109/ /pubmed/35847399 http://dx.doi.org/10.4103/apc.apc_11_21 Text en Copyright: © 2022 Annals of Pediatric Cardiology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Sagiv, Eyal
Chikkabyrappa, Sathish Mallenahalli
Conwell, Jeffrey
Lewin, Mark
Chun, Terrence Un Hoong
Use of Everolimus to treat cardiac rhabdomyomas and incessant arrhythmias in a newborn: Benefits and complications
title Use of Everolimus to treat cardiac rhabdomyomas and incessant arrhythmias in a newborn: Benefits and complications
title_full Use of Everolimus to treat cardiac rhabdomyomas and incessant arrhythmias in a newborn: Benefits and complications
title_fullStr Use of Everolimus to treat cardiac rhabdomyomas and incessant arrhythmias in a newborn: Benefits and complications
title_full_unstemmed Use of Everolimus to treat cardiac rhabdomyomas and incessant arrhythmias in a newborn: Benefits and complications
title_short Use of Everolimus to treat cardiac rhabdomyomas and incessant arrhythmias in a newborn: Benefits and complications
title_sort use of everolimus to treat cardiac rhabdomyomas and incessant arrhythmias in a newborn: benefits and complications
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280109/
https://www.ncbi.nlm.nih.gov/pubmed/35847399
http://dx.doi.org/10.4103/apc.apc_11_21
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